Development of a dynamic model for the lung lobes and airway tree in the NCAT phantom

• Published in: IEEE transactions on nuclear science Vol. 50; no. 3; pp. 378 - 383
• Main Authors: Garrity, J.M., Segars, W.P., Knisley, S.B., Tsui, B.M.W.
• Format: Journal Article
• Language: English
• Published: New York IEEE 01.06.2003; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Airways; Brain modeling; Computed tomography; Dynamic models; Human; Human anatomy; Imaging phantoms; Lobes; Lungs; Magnetic resonance imaging; Mathematical model; Mathematical models; Spline; Studies; Surface reconstruction; Surface topography; Trees; Tubes
• ISSN: 0018-9499; 1558-1578
• DOI: 10.1109/TNS.2003.812445

The four-dimensional (4-D) NCAT phantom was developed to realistically model human anatomy based on the visible human data and cardiac and respiratory motions based on 4-D tagged magnetic resonance imaging and respiratory-gated CT data from normal human subjects. Currently, the 4-D NCAT phantom does not include the airway tree or its motion within the lungs. Also, each lung is defined with a single surface; the individual lobes are not distinguished. The authors further the development of the phantom by creating dynamic models for the individual lung lobes and for the airway tree in each lobe. NURBS surfaces for the lobes and an initial airway tree model (/spl sim/ 4 generations) were created through manual segmentation of the visible human data. A mathematical algorithm with physiological constraints was used to extend the original airway model to fill each lobe. For each parent airway branch inside a lobe, the algorithm extends the airway tree by creating two daughter branches modeled with cylindrical tubes. Parameters for the cylindrical tubes such as diameter, length, and angle are constrained based on flow parameters and available lung space.