One-pot Copper Nanoparticle-catalyzed Synthesis of Imidazo[1,2-α]pyridines Under Solvent-free Conditions

• Published in: Chemical research in Chinese universities Vol. 30; no. 4; pp. 632 - 638
• Main Authors: Zong, Chenglong, Zeng, Runsheng, Zou, Jianping
• Format: Journal Article
• Language: English
• Published: Heidelberg Jilin University and The Editorial Department of Chemical Research in Chinese Universities 01.08.2014; Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R.China
• Subjects: 2-氨基吡啶; Analytical Chemistry; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Inorganic Chemistry; Organic Chemistry; Physical Chemistry; 一锅反应; 催化合成; 取代咪唑; 快速访问; 无溶剂条件; 铜纳米粒子; 铜纳米颗粒; Three-component reaction; 2-Aminopyridine; Aldehyde; Copper nanoparticle; Solvent-free condition; Alkyne
• ISSN: 1005-9040; 2210-3171
• DOI: 10.1007/s40242-014-3520-5

A direct and efficient approach to synthesize imidazo[1,2-α]pyridines through three-component one-pot reaction of 2-aminopyridine,aldehyde and terminal alkyne catalyzed by Cu-nanoparticles under solvent-free conditions has been developed.This method provides a rapid access to substituted imidazo[1,2-α]pyridines with good yields（up to 85％）.