Construction of a sensitive electrochemical sensor based on 1T-MoS2 nanosheets decorated with shape-controlled gold nanostructures for the voltammetric determination of doxorubicin

• Published in: Mikrochimica acta (1966) Vol. 187; no. 4; p. 223
• Main Authors: Er, Engin, Erk, Nevin
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.04.2020; Springer Nature B.V
• Subjects: Adsorptivity; Analytical Chemistry; Characterization and Evaluation of Materials; Chemical sensors; Chemistry; Chemistry and Materials Science; Doxorubicin; Electrochemical analysis; Gold; Microengineering; Molybdenum disulfide; Morphology; Nanochemistry; Nanocomposites; Nanorods; Nanosheets; Nanospheres; Nanostructure; Nanotechnology; Original Paper; Single crystals; Voltammetry; X ray photoelectron spectroscopy; Electrochemical determination; Molybdenum disulfide; Modified electrode; Gold nanostructures; Anticancer drugs; Serum analysis; Transition metal dichalcogenides; Doxorubicin; Chemical exfoliation
• ISSN: 0026-3672; 1436-5073
• DOI: 10.1007/s00604-020-4206-y

An innovative and portable design to fabricate an electrochemical sensor based on metallic phase MoS 2 (1T-MoS 2 ) decorated with shape-dependent gold nanostructures for the determination of doxorubicin (DOX) is presented. In this context, homogenous and uniform single-crystal gold nanospheres (AuNSPs) and nanorods (AuNRDs) were firstly synthesized by seeded growth approach. Afterwards, AuNSPs and AuNRDs were anchored on 1T-MoS 2 surfaces to construct the desired electrochemical sensing platform towards the DOX assay. 1T-MoS 2 was exfoliated by metal intercalation process using NaK metal alloys. The structure and surface morphology of 1T-MoS 2 , AuNSPs, and AuNRDs were characterized by XPS, Raman, UV-vis, TEM, and SEM. The electrochemical behavior of DOX using various MoS 2 -based electrochemical sensors prepared on screen-printed electrode (SPE) was examined by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The electrocatalytic efficiency of AuNRDs on 1T-MoS 2 was also compared with that of AuNSPs on 1T-MoS 2 , and it showed much better electrocatalytic activity towards the DOX. A nanocomposite prepared with AuNRDs and 1T-MoS 2 on SPE (AuNRDs/1T-MoS 2 /SPE) exhibited a linear relationship between peak current and DOX concentration in the range 0.01–9.5 μM with a detection limit of 2.5 nM. The AuNRDs/1T-MoS 2 /SPE was successfully applied to the sensitive and rapid determination of DOX in spiked human serum samples with satisfactory recoveries in the range 99.2–100.8%. Graphical abstract Schematic representation of a portable design for electrochemical sensor based on shape-controlled gold nanostructures decorated on metallic phase molybdenum disulfide (1T-MoS 2 ) towards the sensitive determination of doxorubicin.