New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides
Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as H...
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Published in | Tetrahedron letters Vol. 45; no. 29; pp. 5611 - 5613 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
12.07.2004
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Subjects | |
Online Access | Get full text |
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Summary: | Hydrates of trifluoropyruvamides are readily obtained from isocyanides and trifluoroacetic anhydride. Under catalysis with secondary amines, these hydrates were successfully reacted with various methylketones to form fluorinated aldol type compounds. The effect of the amine is discussed as well as Henry type additions with nitromethane. (C) 2004 Elsevier Ltd. All rights reserved. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2004.05.128 |