Biochemical markers of virus cytopathogenicity in macrophages

The results of macrophage metabolism studies at their infection by viruses differing in the level of virulence are presented. With the purpose of optimizing the estimation of viral cytopathogenic effects on macrophages, an index of cell reactions, which allows one to reveal the degree of virus influ...

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Published inApplied biochemistry and microbiology Vol. 49; no. 1; pp. 64 - 72
Main Authors Plekhova, N. G., Somova, L. M., Krylova, N. V., Leonova, G. N., Lyapun, I. N., Smirnov, I. S.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 2013
Springer Nature B.V
Subjects
Biochemistry
Biomarkers
Biomedical and Life Sciences
Life Sciences
Medical Microbiology
Microbiology
Pathology
Virology
Nitric Oxide
Stimulation Index
Tick Bear Encephalitis
Nitroxide
Apply Biochemistry
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Summary:The results of macrophage metabolism studies at their infection by viruses differing in the level of virulence are presented. With the purpose of optimizing the estimation of viral cytopathogenic effects on macrophages, an index of cell reactions, which allows one to reveal the degree of virus influence in standard units, is offered. Generally, the application of high-sensitivity methods for functional activity determination and identification of the correlative communication between its changes and morphological features of cells can be prescribed to objective identification methods of not only viral reproduction, but also differentiation of types and the degree of their cytopathogenic effects.
Bibliography:ObjectType-Article-1
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ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683813010158