Engineering of non-natural receptors

Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical...

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Bibliographic Details
Published inCurrent opinion in structural biology Vol. 14; no. 4; pp. 505 - 511
Main Authors Mathonet, Pascale, Fastrez, Jacques
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2004
Subjects
Binding Sites
Biosensing Techniques
Carrier Proteins - chemistry
Carrier Proteins - metabolism
Computer-Aided Design
Models, Molecular
Protein Engineering - methods
Structure-Activity Relationship
PBPperiplasmic binding protein
LPSlipopolysaccharide
GFPgreen fluorescent protein
PDBProtein Data Bank
EGFPenhanced GFP
FRETfluorescence resonance energy transfer
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Summary:Rational design, usually guided by computational prediction, and selection from libraries of variants of natural proteins have been used with success in the engineering of novel non-natural receptors. Many of these engineered protein binders will find use in biotechnological, diagnostic and medical applications, sometimes in the place of natural antibodies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2004.06.007