Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats

Evidence for increased glucocorticoid 6 beta-hydroxylation (enhanced family 3A cytochrome P-450 activity) is found in certain reversible forms of human hypertension. This association was investigated in the spontaneously hypertensive rat (SHR). The proportion of injected [3H]corticosterone excreted...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 262; no. 6 Pt 2; pp. F927 - F931
Main Authors Watlington, C O, Kramer, L B, Schuetz, E G, Zilai, J, Grogan, W M, Guzelian, P, Gizek, F, Schoolwerth, A C
Format Journal Article
LanguageEnglish
Published United States 01.06.1992
Subjects
Animals
Blood Pressure
Corticosterone - analogs & derivatives
Corticosterone - biosynthesis
Corticosterone - urine
Rats
Rats, Inbred SHR
Rats, Inbred WKY - metabolism
Systole
Troleandomycin - pharmacology
Online AccessGet full text

Cover

More Information
Summary:Evidence for increased glucocorticoid 6 beta-hydroxylation (enhanced family 3A cytochrome P-450 activity) is found in certain reversible forms of human hypertension. This association was investigated in the spontaneously hypertensive rat (SHR). The proportion of injected [3H]corticosterone excreted in urine as 6 beta-[3H]OH-corticosterone was four- to fivefold higher in SHR than in control Wistar-Kyoto rats, before and after development of overt hypertension. Both hypertension and 6 beta-hydroxylation were inhibited by troleandomycin (a selective inhibitor of family 3A cytochromes P-450), consistent with a role for increased steroid 6 beta-hydroxylation in the genesis of hypertension in the SHR.
ISSN:0002-9513
1931-857X
1522-1466
DOI:10.1152/ajprenal.1992.262.6.F927