Aminopropyl-silica functionalized with halogen-reactive compounds for antimicrobial applications

• Published in: Materials chemistry and physics Vol. 241; p. 122353
• Main Authors: Zarafu, Irina, Jebur Al Taweel, Ali Abed, Limban, Carmen, Popa, Marcela, Măruțescu, Luminița, Chifiriuc, Mariana Carmen, Pircalabioru, Gratiela Gradisteanu, Culiță, Daniela, Ghica, Corneliu, Ionita, Petre
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.02.2020; Elsevier BV
• Subjects: Aminopropyl silica; Antiinfectives and antibacterials; Biological evaluation; E coli; Inorganic materials; Microorganisms; Morphology; Nanomaterials; Nanoparticle; Nanoparticles; Organic compounds; Pseudomonas aeruginosa; Silica; Silicon dioxide; Structural analysis; Synthesis; Synthesis; Biological evaluation; Nanoparticle; Silica; Structural analysis
• ISSN: 0254-0584; 1879-3312
• DOI: 10.1016/j.matchemphys.2019.122353

Aminopropyl-silica nanoparticles S0 were obtained and further functionalized with eight halogen-reactive organic compounds 1–8, leading to the S1–S8 hybrid organic-inorganic materials, with spherical morphology and having a 50–200 nm size, as showed TEM analysis. These were further characterized by IR and DLS. Biological assays were performed using five microbial strains, belonging to species frequently encountered in the aetiology of human infections (Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans). The obtained materials exhibited promising antimicrobial properties, being active against planktonic, but particularly on biofilm-embedded cells. Among the tested hybrid nanomaterials, S6 seemed to exhibit the most promising antimicrobial profile. [Display omitted] •Aminopropyl-silica nanoparticles synthetized.•Functionalized with 8 halogeno-reactive organic compounds.•Characterised by IR, TEM, DLS.•Biological assays were performed using five microbial strains.•Active both against planktonic and biofilm-embedded cells.