Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization
Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high...
Saved in:
Published in | Mass spectrometry letters Vol. 3; no. 1; pp. 15 - 17 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
한국질량분석학회
01.03.2012
사단법인 한국질량분석학회 |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl(TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes couldbe identified by GC-MS after the derivatization. Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl (TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes could be identified by GC-MS after the derivatization. KCI Citation Count: 2 |
---|---|
AbstractList | Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl(TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes couldbe identified by GC-MS after the derivatization. Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without derivatization, but hydroxyhongdenafil, hydroxyvardenafil, xanthoanthrafil andmirodenafil could not be identified without derivatization for the high polarity due to the presence of hydroxyl groups. N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) and N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide (MTBSTFA), widely used trimethylsilyl (TMS) derivatizing reagents, were used to improve the sensitivity of the hydroxylated analogues. And the analytes could be identified by GC-MS after the derivatization. KCI Citation Count: 2 |
Author | Jaesung Pyo Yujin Park Jaesin Lee Yonghoon Park Heesang Lee Sanggil Choe Miyoung Lee Jiyeong Jo |
Author_xml | – sequence: 1 fullname: Jaesung Pyo – sequence: 2 fullname: Heesang Lee – sequence: 3 fullname: Yujin Park – sequence: 4 fullname: Jiyeong Jo – sequence: 5 fullname: Yonghoon Park – sequence: 6 fullname: Sanggil Choe – sequence: 7 fullname: Miyoung Lee – sequence: 8 fullname: Jaesin Lee |
BackLink | https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001912029$$DAccess content in National Research Foundation of Korea (NRF) |
BookMark | eNotjE1PwkAURSdGExHZu5yNCxet89l2loQikoAYwYWr5nU6hRGYmmkxwV_vBHjJy7nJvTl36No1ziD0QEksRZo9z5ezmBHKYh7TmFB5hXqMKB5lSpLrkBnnkWCE36JB236TcImknGc99JWbzvi9ddDZxuGmxt3G4Pd8HEk8dRtb2q7xLQZX4dXGWI-HDnbN-mBaXB7xZBTNl-cyMDfe_gbP38l1j25q2LVmcGEffb6MV6PXaLaYTEfDWaS5UF3EqAZFtBZG1AZqkgiVlIYSKUrNS8J1-CpJoaJlKpTWkJJEARAQIgXNM95HT2ev83Wx1bZowJ64boqtL4Yfq2lBGREsVWH7eNkevN2bykLxEwL4Y_G2yMeUSiFllvB_UfRjzg |
CitedBy_id | crossref_primary_10_1016_j_jpba_2012_10_013 crossref_primary_10_1039_D2AY00580H crossref_primary_10_5478_MSL_2012_3_2_50 crossref_primary_10_1016_j_ultsonch_2023_106611 crossref_primary_10_1016_j_jpba_2016_01_034 crossref_primary_10_1016_j_chroma_2020_461210 |
ContentType | Journal Article |
DBID | DBRKI TDB ACYCR |
DOI | 10.5478/MSL.2012.3.1.015 |
DatabaseName | DBPIA - 디비피아 Korean Database (DBpia) Korean Citation Index |
DatabaseTitleList | |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 2093-8950 |
EndPage | 17 |
ExternalDocumentID | oai_kci_go_kr_ARTI_1204279 NODE11545586 |
GroupedDBID | .UV 5VS 9ZL AAFWJ ADBBV AFPKN ALMA_UNASSIGNED_HOLDINGS BCNDV DBRKI GROUPED_DOAJ GW5 HZB IPNFZ JDI KQ8 KVFHK M~E RIG TDB ACYCR |
ID | FETCH-LOGICAL-c349t-21ca90cc4e4feaf06496be1054bc3b03cb03d67ad1b749cca7069aa0a447ac383 |
ISSN | 2233-4203 |
IngestDate | Tue Nov 21 21:44:39 EST 2023 Fri Oct 18 15:23:37 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Keywords | GC-MS MTBSTFA PDE-5 inhibitor BSTFA TMS derivatization |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c349t-21ca90cc4e4feaf06496be1054bc3b03cb03d67ad1b749cca7069aa0a447ac383 |
Notes | G704-SER000003866.2012.3.1.005 |
OpenAccessLink | https://msletters.accesson.kr/assets/pdf/1572/journal-3-1-15.pdf |
PageCount | 3 |
ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_1204279 nurimedia_primary_NODE11545586 |
PublicationCentury | 2000 |
PublicationDate | 2012-03-01 |
PublicationDateYYYYMMDD | 2012-03-01 |
PublicationDate_xml | – month: 03 year: 2012 text: 2012-03-01 day: 01 |
PublicationDecade | 2010 |
PublicationTitle | Mass spectrometry letters |
PublicationYear | 2012 |
Publisher | 한국질량분석학회 사단법인 한국질량분석학회 |
Publisher_xml | – name: 한국질량분석학회 – name: 사단법인 한국질량분석학회 |
SSID | ssj0000651338 ssib053376805 |
Score | 1.9169534 |
Snippet | Eighteen of the PDE-5 inhibitors and their analogues were analyzed using GC-EI-MS. Fourteen of them could beidentified by simple GC-MS method without... |
SourceID | nrf nurimedia |
SourceType | Open Website Publisher |
StartPage | 15 |
SubjectTerms | 화학 |
Title | Determination of the PDE-5 Inhibitors and Their Analogues by GC-MS and TMS Derivatization |
URI | https://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE11545586 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART001912029 |
Volume | 3 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
ispartofPNX | Mass Spectrometry Letters, 2012, 3(1), , pp.15-17 |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKeIAXBAzE-JgshHmpUpzESezHtMkYExuT6KTtKXISZ5SJFrXpQ_df8h9x5_QjrUAaPNRx4g-5ucv557PvjpB3keSlyzV3YCpRjqi8ytG-rhyARqEpeFlq67vz9Cw8vhAnl8Flp_OrdWppXue94vaPdiX_Q1V4BnRFK9l_oOy6U3gAeaAvpEBhSO9E42R1lmUF-xBFniepE8B3_22Uj2woHVSND-1-AHogQVXNDEHnx4EDi3hbCNcExova2dsNpVZxngBed61BJno2qKcYacL65FwfvtFmBiKje76YbDSrZqbRfMqs-eZq_n0E8rZlGnQyWhiMdHQyaase8AyH31Y9sHTApMfiAUv7TPZZLDHT95gKsEglrC-7LE3wXkGlmPUDFidYFkdM2trqiEllm4VMCtujwJbLVspmYiYHG7kIgMZ3hMcbuWiaZ1z5jlSND9ulLG7MRJezemMgujtfoDMzIPLp1894yM_r-T23x1ft2q65d6bMLefcN8Uou55kN9MMliCfMtfD8CXqHrkPaRC0VvkNOMCAOjZO4upvNJvnOJQPuwMBwDOeAk56MJ5jsAeQGC3wM3xMHi1XLTRuWPAJ6ZjxU7IP7FRPfizoe2rPEdsNmn1ytcWVdFJR4EpquZJuuJIC41HLlXTNlTRfUMuVTSFct7nyGbk4SoeDY2cZwMMpfKFqx3MLrXhRCCMqoytAvyrMDSB6kRd-zv0CfmUY6dLNI6FAlkQ8VFpzLUSkC1_6z8neeDI2LwiFKtKtqkjrqBKl5-cCGnswU_OgjIqqOCBv4U1ZWvydJgfkcP0is5-NN5fs7EuSok-qIJDhy7v08oo83HwMr8lePZ2bN4BM6_zQ0vo39RaBHA |
link.rule.ids | 315,786,790,870,27955,27956 |
linkProvider | Directory of Open Access Journals |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Determination+of+the+PDE-5+Inhibitors+and+Their+Analogues+by+GC-MS+and+TMS+Derivatization&rft.jtitle=Mass+spectrometry+letters&rft.au=Jaesung+Pyo&rft.au=Heesang+Lee&rft.au=Yujin+Park&rft.au=Jiyeong+Jo&rft.date=2012-03-01&rft.pub=%EC%82%AC%EB%8B%A8%EB%B2%95%EC%9D%B8+%ED%95%9C%EA%B5%AD%EC%A7%88%EB%9F%89%EB%B6%84%EC%84%9D%ED%95%99%ED%9A%8C&rft.issn=2233-4203&rft.eissn=2093-8950&rft.spage=15&rft.epage=17&rft_id=info:doi/10.5478%2FMSL.2012.3.1.015&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_1204279 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2233-4203&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2233-4203&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2233-4203&client=summon |