IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

• Published in: Developmental and comparative immunology Vol. 29; no. 3; pp. 185 - 203
• Main Authors: Lefranc, Marie-Paule, Pommié, Christelle, Kaas, Quentin, Duprat, Elodie, Bosc, Nathalie, Guiraudou, Delphine, Jean, Christelle, Ruiz, Manuel, Da Piédade, Isabelle, Rouard, Mathieu, Foulquier, Elodie, Thouvenin, Valérie, Lefranc, Gérard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 2005
• Subjects: Amino Acid Sequence; C-set; Colliers de Perles; Constant domain; Humans; IMGT; Immunoglobulin; Immunoglobulin superfamily; Immunoglobulins; Internet; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Antigen, T-Cell; Sequence Analysis, DNA; Sequence Analysis, Protein; T cell receptor; Terminology as Topic; V-set; T cell receptor; Colliers de Perles; MHC; Immunoglobulin; RPI; Constant domain; 3D; 2D; IMGT; IgSF; Immunoglobulin superfamily; V-set; C-set; IG; TR
• ISSN: 0145-305X; 1879-0089
• DOI: 10.1016/j.dci.2004.07.003

IMGT, the international ImMunoGeneTics information system ® ( http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs. In this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species.