Development of (acrylic acid/ polyethylene glycol)-zinc oxide mucoadhesive nanocomposites for buccal administration of propranolol HCl

• Published in: Radiation physics and chemistry (Oxford, England : 1993) Vol. 147; pp. 18 - 26
• Main Authors: Mahmoud, Ghada A., Ali, Amr El-Hag, Raafat, Amany I., Badawy, Nagwa A., Elshahawy, Mai. F.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2018; Elsevier BV
• Subjects: Acrylic acid; Antibacterial; Buccal drug delivery; Copolymerization; Drug delivery systems; E coli; Energy dispersive X ray spectroscopy; Graft copolymers; Hydrogels; Microorganisms; Mucoadhesive; Nanocomposites; Nanoparticles; Polyethylene glycol; Saliva; Scanning electron microscopy; Self disinfection; Stability analysis; Thermal stability; Thermogravimetric analysis; X-ray diffraction; Zinc oxide; Zinc oxides; ZnO nanocomposites; γ-Irradiation; ZnO nanocomposites; Self disinfection; Buccal drug delivery; Antibacterial; Mucoadhesive; γ-Irradiation
• ISSN: 0969-806X; 1879-0895
• DOI: 10.1016/j.radphyschem.2018.01.020

A series of mucoadhesive nanocomposites with self disinfection properties composed of acrylic acid, polyethylene glycol and ZnO nanoparticles (AAc/PEG)-ZnO were developed for localized buccal Propranolol HCl delivery. γ-irradiation as a clean tool for graft copolymerization process was used for the preparation of (AAc/PEG) hydrogels. In suite precipitation technique was used for ZnO nanoparticles immobilization within (AAc/PEG) hydrogels. The developed (AAc/PEG)-ZnO nanocomposites were characterized by X-ray diffraction (XRD), UV–Vis spectrophotometer, energy dispersive X-ray spectroscopy (EDX) and scanning electron microscopy (SEM) to confirm the success of ZnO nanoparticles formation within the (AAc/PEG) matrices. The presence of ZnO nanoparticles improves the thermal stability as indicated using thermogravimetric analysis (TGA). The mucoadhesion characteristics such as hydration degree, surface pH, and mucoadhesive strength were evaluated in artificial saliva solution. The self disinfection property of the developed (AAc/PEG)-ZnO nanocomposites was investigated by examining their resistance to pathogenic microorganisms such as Staphylococcus aureus, Bacillus subtilis, and Escherichia coli using disc diffusion method. The release of Propranolol -HCl drug in artificial saliva was found to obey a non-Fickian diffusion mechanism. The obtained results suggests that (AAc/PEG)-ZnO nanocomposites could be used as mucoadhesive carrier for buccal drug delivery with efficient antibacterial properties. •γ-irradiation was employed to prepare a novel mucoadhesive (AAc/PEG) hydrogel.•The self-disinfection properties acquired via the in-situ deposition of ZnO nanoparticles.•In addition to the mucoadhesion property, the thermal and swelling characteristics were improved.•The Propranolol-HCl loaded nanocomposites show the ability to regulate the drug release.•The high mucoadhesive strength ensures drug delivery via buccal mucosa.