Oxidative stress in adipose tissue as a primary link in pathogenesis of insulin resistance

Obesity is a leading risk factor of diabetes mellitus type 2 (DM2), impairments of lipid metabolism and cardiovascular diseases. Dysfunctions of the accumulating weight of the visceral fat are primarily linked to pathogenesis of systemic insulin resistance. The review considers modern viewpoints on...

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Published inBiochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 10; no. 3; pp. 212 - 219
Main Authors Kuzmenko, D. I., Udintsev, S. N., Klimentyeva, T. K., Serebrov, V. Yu
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.07.2016
Springer Nature B.V
Subjects
Adipocytes
Biochemistry
Bioorganic Chemistry
Body fat
Chemistry
Chemistry and Materials Science
Diabetes
Insulin resistance
Medicinal Chemistry
Oxidative stress
Pathogenesis
insulin resistance
diabetes
oxidative stress
adipocyte
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Summary:Obesity is a leading risk factor of diabetes mellitus type 2 (DM2), impairments of lipid metabolism and cardiovascular diseases. Dysfunctions of the accumulating weight of the visceral fat are primarily linked to pathogenesis of systemic insulin resistance. The review considers modern viewpoints on biochemical mechanisms underlying formation of oxidative stress in adipocytes at obesity, as one of key elements responsible for impairments of their metabolism triggering formation of systemic insulin resistance.
Bibliography:ObjectType-Article-1
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ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750816030100