Causal inference with noisy data: Bias analysis and estimation approaches to simultaneously addressing missingness and misclassification in binary outcomes

• Published in: Statistics in medicine Vol. 39; no. 4; pp. 456 - 468
• Main Authors: Shu, Di, Yi, Grace Y.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 20.02.2020
• Subjects: causal inference; double robustness; inverse probability weighting; Medical research; misclassification; Missing data; Statistical inference; double robustness; inverse probability weighting; causal inference; missing data; misclassification
• ISSN: 0277-6715; 1097-0258; 1097-0258
• DOI: 10.1002/sim.8419

Causal inference has been widely conducted in various fields and many methods have been proposed for different settings. However, for noisy data with both mismeasurements and missing observations, those methods often break down. In this paper, we consider a problem that binary outcomes are subject to both missingness and misclassification, when the interest is in estimation of the average treatment effects (ATE). We examine the asymptotic biases caused by ignoring missingness and/or misclassification and establish the intrinsic connections between missingness effects and misclassification effects on the estimation of ATE. We develop valid weighted estimation methods to simultaneously correct for missingness and misclassification effects. To provide protection against model misspecification, we further propose a doubly robust correction method which yields consistent estimators when either the treatment model or the outcome model is misspecified. Simulation studies are conducted to assess the performance of the proposed methods. An application to smoking cessation data is reported to illustrate the use of the proposed methods.