An application of the mixed‐effects model and pattern mixture model to treatment groups with differential missingness suspected not‐missing‐at‐random

• Published in: Pharmaceutical statistics : the journal of the pharmaceutical industry Vol. 20; no. 1; pp. 93 - 108
• Main Authors: Gosho, Masahiko, Maruo, Kazushi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Inc 01.01.2021; Wiley Subscription Services, Inc
• Subjects: missing at random; missingness‐data pattern; mixed effects models for repeated measures; not missing at random; Sensitivity analysis; Statistical analysis; Within-subjects design; missing at random; missingness-data pattern; not missing at random; sensitivity analysis; mixed effects models for repeated measures
• ISSN: 1539-1604; 1539-1612; 1539-1612
• DOI: 10.1002/pst.2058

Summary Likelihood‐based, mixed‐effects models for repeated measures (MMRMs) are occasionally used in primary analyses for group comparisons of incomplete continuous longitudinal data. Although MMRM analysis is generally valid under missing‐at‐random assumptions, it is invalid under not‐missing‐at‐random (NMAR) assumptions. We consider the possibility of bias of estimated treatment effect using standard MMRM analysis in a motivational case, and propose simple and easily implementable pattern mixture models within the framework of mixed‐effects modeling, to handle the NMAR data with differential missingness between treatment groups. The proposed models are a new form of pattern mixture model that employ a categorical time variable when modeling the outcome and a continuous time variable when modeling the missingness‐data patterns. The models can directly provide an overall estimate of the treatment effect of interest using the average of the distribution of the missingness indicator and a categorical time variable in the same manner as MMRM analysis. Our simulation results indicate that the bias of the treatment effect for MMRM analysis was considerably larger than that for the pattern mixture model analysis under NMAR assumptions. In the case study, it would be dangerous to interpret only the results of the MMRM analysis, and the proposed pattern mixture model would be useful as a sensitivity analysis for treatment effect evaluation.