Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials

• Published in: Phytotherapy research Vol. 35; no. 12; pp. 6607 - 6623
• Main Authors: Shahinfar, Hossein, Bazshahi, Elham, Amini, Mohammad Reza, Payandeh, Nastaran, Pourreza, Sanaz, Noruzi, Zahra, Shab‐Bidar, Sakineh
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2021; Wiley Subscription Services, Inc
• Subjects: artichoke juice; artichoke leaf extract; Artichokes; Cynara scolymus; Dietary Supplements; dose–response meta‐analysis; High density lipoprotein; hyperlipidemia; lipid profile; Lipids; Meta-analysis; Plant extracts; Plant Extracts - pharmacology; randomized clinical trial; Randomized Controlled Trials as Topic; Supplements; dose-response meta-analysis; randomized clinical trial; hyperlipidemia; artichoke juice; artichoke leaf extract; lipid profile
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.7247

Accumulating evidence regarding the effect of artichoke on lipid profile is equivocal. We updated a previous meta‐analysis on the effect of artichoke extract supplementation on lipid profile and performed dose–response analysis. We searched PubMed, Scopus, Web of Science, and Cochrane Library from inception to June 2021 using relevant keywords. Papers from identified articles were collected. Two researchers rated the certainty in the estimates using the GRADE approach. Combining 15 effect sizes from 14 studies based on the random‐effects analysis, we found that artichoke significantly reduced TG (weighed mean difference [WMD]: −17.01 mg/dl, 95% CI: −23.88, −10.13, p = .011), TC (WMD: −17.01 mg/dl, 95% CI: −23.88, −10.13, p < .001), and LDL‐C (WMD: −17.48 mg/dl, 95%CI: −25.44, −9.53, p < .001). No significant effect of artichoke on HDL‐C level was detected (WMD: 0.78 mg/dl, 95%CI: −0.93, 2.49, p = .371). Combining the two effect sizes revealed that artichoke juice supplementation significantly reduced TG (WMD: −3.34 mg/dl, 95%CI: −5.51, −1.17, p = .003), TC (WMD: −18.04 mg/dl, 95%CI: −20.30, −15.78, p < .001), LDL‐C (WMD: −1.75 mg/dl, 95%CI: −3.02, −0.48, p = .007), and HDL‐C levels (WMD: −4.21 mg/dl, 95%CI: −5.49, −2.93, p < .001). In conclusion, we found that artichoke supplementation may favor CVD prevention by acting in improving the lipid profile.