The mediation of macrophage reaction in inflammation, with special reference to IgG-derived chemotactic factor

Three different macrophage chemotactic factors were separated from hypersensitivity skin lesions induced by DNP-ascaris extract or PPD. The amount of each factor seemed to be changeable according to the nature of inflammatory stimuli. The chemotactic activity of the factor a was completely absorbed...

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Bibliographic Details
Published inActa pathologica japonica Vol. 28; no. 5; p. 677
Main Authors Hayashi, H, Hirashima, M, Honda, M, Ishida, M
Format Journal Article
LanguageEnglish
Published Australia 01.09.1978
Subjects
Animals
Antigens
Ascaris - immunology
Chemotaxis, Leukocyte
Dinitrophenols - immunology
Guinea Pigs
Hypersensitivity, Delayed - immunology
Immunoglobulin G - immunology
Inflammation - immunology
Macrophages - analysis
Neutrophils - enzymology
Peptide Hydrolases - metabolism
Skin - immunology
Tuberculin - immunology
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Summary:Three different macrophage chemotactic factors were separated from hypersensitivity skin lesions induced by DNP-ascaris extract or PPD. The amount of each factor seemed to be changeable according to the nature of inflammatory stimuli. The chemotactic activity of the factor a was completely absorbed by anti-IgG and anti-light chain antibodies, while that of the factors b and c was not absorbed by the antibodies. The factor a was produced from IgG by neutrophil neutral serine protease resembling elastase but failing to digest elastin-orcein; its chemotactic generation was accompanied by release of dialysable peptide(s) from the IgG molecule, suggesting a minor structural change of the IgG molecule. Production of leucoegresin or lymphocyte chemotactic factor by neutrophil neutral thiol protease from IgG molecule was discussed.
ISSN:0001-6632
DOI:10.1111/j.1440-1827.1978.tb00907.x