Specific IgE response toward allergenic molecules during perennial hyposensitization: a three year prospective double-blind study
Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radi...
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| Published in | Journal of allergy and clinical immunology Vol. 71; no. 1; pp. 40 - 46 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Mosby, Inc
1983
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radioimmunoelectrophoresis. The patients exhibited specific IgE response toward individual allergenic molecules, and IgE with new specificities did not develop after hyposensitization. A high degree of clinical protection could generally be obtained on treatment with the 20-component timothy extract, but this was true only with the two-component timothy extract containing the allergenic molecules that matched the individual IgE response. |
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| AbstractList | Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radioimmunoelectrophoresis. The patients exhibited specific IgE response toward individual allergenic molecules, and IgE with new specificities did not develop after hyposensitization. A high degree of clinical protection could generally be obtained on treatment with the 20-component timothy extract, but this was true only with the two-component timothy extract containing the allergenic molecules that matched the individual IgE response. Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radioimmunoelectrophoresis. The patients exhibtied specific IgE response toward individual allergenic molecules, and IgE with new specificities did not develop after hyposensitization. A high degree of clinical protection could generally be obtained on treatment with the 20-component timothy extract, but this was true only with the two-component timothy extract containing the allergenic molecules that matched the individual IgE response. |
| Author | Ipsen, Henrik Weeke, Bent Østerballe, Ole Løwenstein, Henning |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6337196$$D View this record in MEDLINE/PubMed |
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| References | Marsh (BIB2) 1975; vol. 3 Kjellman, Lanner (BIB5) 1980; 35 Løwenstein (BIB6) 1981 Løwenstein (BIB11) 1978; 33 Østerballe, Løwenstein, Malling, Petersen, Weeke (BIB13) 1982; 68 Aas, Backman, Belin, Weeke (BIB12) 1978; 33 Østerballe, Løwenstein, Norn, Prahl, Skov, Skov, Weeke (BIB10) 1982; 37 Østerballe (BIB7) 1980; 35 Frostad, Grimmer, Sandvik, Aas (BIB4) 1980; 35 Østerballe (BIB8) 1982; 37 Løwenstein (BIB1) 1978; 25 Berg, Nordvall, Lanner (BIB3) 1980; 63 Østerballe, Løwenstein, Prahl, Skov, Weeke (BIB9) 1981; 36 |
| References_xml | – volume: 33 start-page: 30 year: 1978 ident: BIB11 article-title: Isolation and partial characterization of three allergens of timothy pollen publication-title: Allergy contributor: fullname: Løwenstein – volume: 25 start-page: 1 year: 1978 ident: BIB1 article-title: Quantitative immunoelectrophoretic methods as a tool for the analysis and isolation of allergen publication-title: Prog Allergy contributor: fullname: Løwenstein – volume: 68 start-page: 286 year: 1982 ident: BIB13 article-title: Is it possible to predict clinical effect of hyposensitization? publication-title: Int Arch Allergy Appl Immunol contributor: fullname: Weeke – volume: vol. 3 start-page: 271 year: 1975 end-page: 359 ident: BIB2 article-title: Allergens and genetics of allergy publication-title: The antigens contributor: fullname: Marsh – volume: 63 start-page: 266 year: 1980 ident: BIB3 article-title: Clinical studies of a purified timothy pollen extract. Desensitization therapy with a purified timothy pollen preparation compared to a crude timothy pollen extract. I. Results of tests publication-title: Int Arch Allergy contributor: fullname: Lanner – volume: 35 start-page: 323 year: 1980 ident: BIB5 article-title: Hyposensitization in childhood hay fever. A comparison of refined and whole timothy extracts publication-title: Allergy contributor: fullname: Lanner – volume: 35 start-page: 473 year: 1980 ident: BIB7 article-title: Immunotherapy in hay fever with two major allergens 19, 25 and partially purified extract of timothy grass pollen. A controlled double blind study. publication-title: Allergy contributor: fullname: Østerballe – volume: 35 start-page: 81 year: 1980 ident: BIB4 article-title: Hyposensitization. Comparing a purified (refined) allergen preparation and a crude aqueous extract from timothy pollen publication-title: Allergy contributor: fullname: Aas – volume: 37 start-page: 491 year: 1982 ident: BIB10 article-title: Immunotherapy with grass pollen major allergens. Immunological results from a prospective 3-year double blind study publication-title: Allergy contributor: fullname: Weeke – volume: 33 start-page: 130 year: 1978 ident: BIB12 article-title: Standardization of allergen extracts by appropriate methods. The combined use of skin prick testing and radioallergosorbent tests publication-title: Allergy contributor: fullname: Weeke – volume: 36 start-page: 183 year: 1981 ident: BIB9 article-title: Immunotherapy in hay fever with two major allergens 19, 25 and partially purified extracts of timothy grass pollen, A controlled double blind study. publication-title: Allergy contributor: fullname: Weeke – volume: 37 start-page: 379 year: 1982 ident: BIB8 article-title: Immunotherapy with grass pollen major allergens. Clinical results from a prospective 3-year double blind study publication-title: Allergy contributor: fullname: Østerballe – start-page: 265 year: 1981 end-page: 274 ident: BIB6 article-title: Technique for definition and identification of allergenic molecules. Possible use for predicting optimal diagnostic and therapeutic extracts publication-title: Clinical immunology and allergology contributor: fullname: Løwenstein |
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| SubjectTerms | Adolescent Adult Allergens - immunology Antibody Specificity Clinical Trials as Topic Desensitization, Immunologic Double-Blind Method Humans Immunoelectrophoresis, Two-Dimensional Immunoglobulin E - analysis Immunoglobulin E - immunology Poaceae Pollen - immunology Prospective Studies Radioimmunoassay Rhinitis, Allergic, Seasonal - immunology Seasons Statistics as Topic |
| Title | Specific IgE response toward allergenic molecules during perennial hyposensitization: a three year prospective double-blind study |
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