Specific IgE response toward allergenic molecules during perennial hyposensitization: a three year prospective double-blind study

• Published in: Journal of allergy and clinical immunology Vol. 71; no. 1; pp. 40 - 46
• Main Authors: Østerballe, Ole, Ipsen, Henrik, Weeke, Bent, Løwenstein, Henning
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 1983
• Subjects: Adolescent; Adult; Allergens - immunology; Antibody Specificity; Clinical Trials as Topic; Desensitization, Immunologic; Double-Blind Method; Humans; Immunoelectrophoresis, Two-Dimensional; Immunoglobulin E - analysis; Immunoglobulin E - immunology; Poaceae; Pollen - immunology; Prospective Studies; Radioimmunoassay; Rhinitis, Allergic, Seasonal - immunology; Seasons; Statistics as Topic; PPA; WPA; BU; CRIE; SRRID; RAST
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/0091-6749(83)90545-6

Allergenic extracts are multicomponent systems containing a number of potentially allergenic molecules. In a 3 yr prospective double-blind study, sera from 40 patients hyposensitized with either a two-component timothy extract or a 20-component timothy extract were evaluated by means of crossed radioimmunoelectrophoresis. The patients exhibited specific IgE response toward individual allergenic molecules, and IgE with new specificities did not develop after hyposensitization. A high degree of clinical protection could generally be obtained on treatment with the 20-component timothy extract, but this was true only with the two-component timothy extract containing the allergenic molecules that matched the individual IgE response.