In vitro antidiabetic, antioxidant, antimicrobial, and cytotoxic activity of Murraya koenigii leaf extract intercedes ZnO nanoparticles

• Published in: Luminescence (Chichester, England) Vol. 38; no. 7; pp. 1139 - 1148
• Main Authors: Sharma, Avinash, Nagraik, Rupak, Venkidasamy, Baskar, Khan, Azhar, Dulta, Kanika, Kumar Chauhan, Pankaj, Kumar, Deepak, Shin, Dong‐Soo
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2023
• Subjects: Analytical methods; Antibacterial activity; antibacterial and cytotoxic activity; Antibiotics; antidiabetic activity; Antioxidants; Biological effects; Cancer; Cytotoxicity; Diabetes mellitus; Electron microscopy; Field emission microscopy; Field emission spectroscopy; Fourier transforms; green synthesis; Herbal medicine; Infrared spectroscopy; Leaves; Light scattering; Medicinal plants; Murraya koenigii; Nanoparticles; Nanotechnology; Photon correlation spectroscopy; Plant extracts; Scanning electron microscopy; Scavenging; Spectroscopy; Synthesis; Zinc; Zinc oxide; zinc oxide nanoparticles; Murraya koenigii; antibacterial and cytotoxic activity; green synthesis; zinc oxide nanoparticles; antidiabetic activity
• ISSN: 1522-7235; 1522-7243
• DOI: 10.1002/bio.4244

Nanotechnology is an emerging field with tremendous potential and usage of medicinal plants and green preparation of nanoparticles (NPs) is one of the widely explored areas. These have been shown to be effective against different biological activities such as diabetes mellitus, cancer, antioxidant, antimicrobial, etc. The current studies focus on the green synthesis of zinc NPs (ZnO NPs) from aqueous leaf extract of Murraya koenigii (MK). The synthesized Murraya koeingii zinc oxide NPs (MK ZnO NPs) were characterized using UV–visible spectroscopy, dynamic light scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), energy‐dispersive spectrum (EDS) and cyclic voltammetry (CV). The synthesized MK ZnO NPs were evaluated for their in vitro antidiabetic, antioxidant, antimicrobial, and cytotoxic activity. They demonstrated significant antidiabetic and cytotoxic activity, as well as moderate free‐radical scavenging and antibacterial activity. Murraya koeingii zinc oxide nanoparticles (MK ZnONPs) prepared via green synthesis, characterized and evaluated for their biological activities. The particle showed significant anti‐diabetic and cytotoxic activity, as well as moderate free‐radical scavenging and antibacterial activity.