Adult ocular medulloepithelioma diagnosed by transscleral fine needle aspiration: A case report

Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years‐old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were...

Full description

Saved in:
Bibliographic Details
Published inDiagnostic cytopathology Vol. 45; no. 6; pp. 561 - 564
Main Authors Mahdjoubi, Amir, Cassoux, Nathalie, Levy‐Gabriel, Christine, Desjardins, Laurence, Klos, Jan, Caly, Martial, Vlajnic, Tatjana, Gardrat, Sophie, Klijanienko, Jerzy
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.06.2017
Subjects
adult
Aged, 80 and over
Biopsy, Fine-Needle - methods
brachytherapy
Case reports
Eye Neoplasms - pathology
Female
fine needle aspiration
Humans
intraocular tumor
medulloepithelioma
Neuroectodermal Tumors, Primitive - pathology
Nuclei (cytology)
transscleral aspiration
medulloepithelioma
intraocular tumor
brachytherapy
adult
transscleral aspiration
fine needle aspiration
Online AccessGet full text

Cover

More Information
Summary:Ocular medulloepithelioma (ME) is a rare congenital tumor which occurs usually during childhood but is also reported in adults. They have seen an intraocular tumor in an 89 years‐old female with a history of small cell lung carcinoma. Transscleral fine needle aspiration was performed. Aspirates were rich and composed of two distinctive populations of cells. The first consisted of epithelioid large cohesive cells with rare rosettes. Nuclei were oval and chromatin was delicate with small nucleoli. The second population consisted of smaller and dispersed cells with regular nuclei and dusty chromatin. Immunohistochemistry performed on paraffin‐embedded cell block sections showed that the larger cells and rosettes were cytokeratin AE1/AE3, Synaptophysin, Chromogranin A, CD56, NSE, and EMA positive, whereas the smaller cells were always negative. Interestingly smaller cells expressed only weak nuclear positivity for TTF1, whereas larger cells were TTF1 negative. Melanocytic markers were negative in both populations. Morphological patterns and immunohistochemical staining confirmed ocular ME and allowed to exclude pulmonary metastasis or primary malignant melanoma. The patient was successfully treated by brachytherapy alone and is alive and well 10 months after treatment. Diagn. Cytopathol. 2017;45:561–564. © 2017 Wiley Periodicals, Inc.
Bibliography:Disclosure of grants or other funding: None
The authors declare that they have no conflicts of interest.
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23694