Advances of phytotherapy in ischemic stroke targeting PI3K/Akt signaling

• Published in: Phytotherapy research Vol. 37; no. 12; pp. 5509 - 5528
• Main Authors: Liu, Tianlong, Wang, Wenjun, Li, Xiaolin, Chen, Yidan, Mu, Fei, Wen, Aidong, Liu, Minna, Ding, Yi
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2023; Wiley Subscription Services, Inc
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Apoptosis; Autophagy; Drug delivery; Drugs; Flavonoids; Herbal medicine; Homeostasis; Humans; Ischemia; ischemic stroke; Ischemic Stroke - drug therapy; Natural products; Neurological complications; Oxidative stress; Pathogenesis; Phenols; Phenylpropanoids; Phosphatidylinositol 3-Kinases - metabolism; Phytotherapy; PI3K/Akt signaling; Plant extracts; Proto-Oncogene Proteins c-akt - metabolism; Quinones; Saponins; Signal transduction; Stroke; Stroke - drug therapy; Stroke - pathology; Terpenes; natural products; PI3K/Akt signaling; phytotherapy; ischemic stroke
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.7994

The pathogenesis of ischemic stroke is complex, and PI3K/Akt signaling is considered to play a crucial role in it. The PI3K/Akt pathway regulates inflammation, oxidative stress, apoptosis, autophagy, and vascular endothelial homeostasis after cerebral ischemia; therefore, drug research targeting the PI3K/Akt pathway has become the focus of scientists. In this review, we analyzed the research reports of antiischemic stroke drugs targeting the PI3K/Akt pathway in the past two decades. Because of the rich sources of natural products, increasing studies have explored the value of natural compounds, including Flavonoids, Quinones, Alkaloids, Phenylpropanoids, Phenols, Saponins, and Terpenoids, in alleviating neurological impairment and achieved satisfactory results. Herbal extracts and medicinal formulas have been applied in the treatment of ischemic stroke for thousands of years in East Asian countries. These precious clinical experiences provide a new avenue for research of antiischemic stroke drugs. Finally, we summarize and discuss the characteristics and shortcomings of the current research and put forward prospects for further in‐depth exploration. Different PI3K/Akt signaling and phytotherapy in ischemic stroke.