Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders

• Published in: Cell biochemistry and function Vol. 42; no. 2; pp. e3964 - n/a
• Main Authors: Nezhad Salari, Amir Mohammad, Rasoulizadeh, Zahra, Shabgah, Arezoo Gowhari, Vakili‐Ghartavol, Roghayyeh, Sargazi, Ghasem, Gholizadeh Navashenaq, Jamshid
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2024
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Alzheimer's disease; Antioxidants; Calcium (mitochondrial); Calcium channels; Channel gating; Clinical trials; Cognitive ability; cognitive function; Disease prevention; Dosage; Effectiveness; Epilepsy; Flavonoids; Fruits; Glioblastoma; Health services; Herbal medicine; In vivo methods and tests; Inflammation; Kaempferol; MAP kinase; Medicinal plants; Movement disorders; Neuralgia; Neuroblastoma; Neurodegeneration; Neurodegenerative diseases; Neurogenesis; neuroinflammation; Neurological diseases; Neurological disorders; neuroprotection; Oxidative stress; Parkinson's disease; Plants (botany); Safety; Signal transduction; Spinal cord injuries; Survival; Vegetables; cognitive function; neurological diseases; kaempferol; neuroinflammation; neuroprotection
• ISSN: 0263-6484; 1099-0844; 1099-0844
• DOI: 10.1002/cbf.3964

Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal cord injury, neuropathic pain, and epilepsy. Numerous in vitro and in vivo investigations have illustrated that kaempferol possesses antioxidant, anti‐inflammatory, and antiapoptotic properties, contributing to its neuroprotective effects. Kaempferol has been shown to modulate key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF‐κB pathways. Moreover, kaempferol exhibits potential therapeutic benefits by enhancing neuronal survival, attenuating oxidative stress, enhancing mitochondrial calcium channel activity, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function. The evidence suggests that kaempferol holds promise as a natural compound for the prevention and treatment of neurological diseases. Further research is warranted to elucidate the underlying mechanisms of action, optimize dosage regimens, and evaluate the safety and efficacy of this intervention in human clinical trials, thereby contributing to the advancement of scientific knowledge in this field. Significance statement Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, to serve as a natural neuroprotective agent for the prevention and treatment of neurological disorders. By conducting an extensive review of the current literature, this study underscores the varied mechanisms through which kaempferol demonstrates its neuroprotective effects, emphasizing its antioxidant, anti‐inflammatory, and antiapoptotic properties. Furthermore, the therapeutic potential of kaempferol in modulating key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF‐κB pathways, is underscored. Additionally, various beneficial effects of kaempferol, including enhancing neuronal survival, attenuating oxidative stress, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function, are emphasized. In summary, compelling evidence is presented supporting the use of kaempferol as a promising natural compound for the prevention and treatment of neurological diseases, thereby indicating the importance of further research to elucidate the mechanisms of action, optimize dosage regimens, and assess the safety and efficacy of kaempferol in human clinical trials.