A case of complete Melkersson‐Rosenthal syndrome: Possibly associated with Mycolicibacterium fortuitum from odontogenic origin

Melkersson‐Rosenthal syndrome (MRS) is a neuromucocutaneous disease of unknown pathogenesis. With this communication, we describe a case of a 26‐year‐old woman with complete MRS in whom Mycolicibacterium fortuitum was detected in the swelling lip biopsy by next‐ generation sequencing. The patient�...

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Bibliographic Details
Published inJournal of dermatology Vol. 50; no. 7; pp. 935 - 937
Main Authors Zhang, Wenqing, Yan, Zhimin
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.07.2023
Subjects
Antibiotics
Biopsy
Case reports
cause
Dental caries
infection
Melkersson‐Rosenthal syndrome
Mycolicibacterium fortuitum
Neurological disorders
odontogenic
Oral diseases
Paralysis
Pathogenesis
Steroids
Mycolicibacterium fortuitum
cause
infection
Melkersson-Rosenthal syndrome
odontogenic
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Summary:Melkersson‐Rosenthal syndrome (MRS) is a neuromucocutaneous disease of unknown pathogenesis. With this communication, we describe a case of a 26‐year‐old woman with complete MRS in whom Mycolicibacterium fortuitum was detected in the swelling lip biopsy by next‐ generation sequencing. The patient's symptoms were slightly improved after intralesional corticosteroid injection combined with broad‐spectrum antibiotics, while they were significantly improved after further treatment of dental caries and removal of the residual root. This case provides insight into the possible microbial infection pathogenesis of MRS, and M. fortuitum was speculated to be related to granulomatous and neuronal disorders, most probably from odontogenic origin.
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ISSN:0385-2407
1346-8138
1346-8138
DOI:10.1111/1346-8138.16751