An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report
Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytologi...
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Published in | Diagnostic cytopathology Vol. 45; no. 7; pp. 634 - 639 |
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Format | Journal Article |
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01.07.2017
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Abstract | Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Cytopathol. 2017;45:634–639. © 2017 Wiley Periodicals, Inc. |
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AbstractList | Carney Complex (CNC) is a rare autosomal dominant condition with characteristic clinical presentation, tumor development, and unique genetic mutation. We present a unique case and literature review of CNC in which two neoplasms characteristic of this complex were initially diagnosed through cytological fine needle aspirate specimens, leading to the identification of CNC, with subsequent surgical and cytogenetic confirmation. Diagn. Cytopathol. 2017;45:634-639. © 2017 Wiley Periodicals, Inc. |
Author | Koenig, Richard Gabriel Mikhail, Fady M. Nix, Jeffrey W. Rosenblum, Frida Eltoum, Isam‐Eldin A. Porterfield, John R. |
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Cites_doi | 10.1016/S1470-2045(05)70244-8 10.1016/S0022-5347(05)65285-8 10.1016/S1096-7192(03)00006-4 10.1530/EJE-15-0209 10.1097/PAS.0b013e3182a0a150 10.1111/j.1365-2303.2010.00740.x 10.1016/S0014-5793(03)00452-6 10.1002/(SICI)1097-0339(199810)19:4<298::AID-DC15>3.0.CO;2-I 10.1002/dc.20593 10.1210/jc.2011-3327 10.1210/jc.2011-2321 10.1097/CCO.0b013e32801195eb |
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References | 2015; 173 2014; 38 2007; 19 2011; 22 2005; 6 1998; 19 2003; 546 2007; 35 2012; 97 2003; 78 2002; 167 e_1_2_4_10_1 e_1_2_4_11_1 e_1_2_4_12_1 e_1_2_4_3_1 e_1_2_4_13_1 e_1_2_4_2_1 e_1_2_4_5_1 e_1_2_4_4_1 e_1_2_4_7_1 e_1_2_4_6_1 e_1_2_4_9_1 e_1_2_4_8_1 |
References_xml | – volume: 19 start-page: 24 year: 2007 end-page: 29 article-title: Carney complex: the first 20 years publication-title: Curr Opin Oncol – volume: 97 start-page: 387 year: 2012 end-page: 390 article-title: Adrenocortical cancer in Carney complex: A paradigm of endocrine tumor progression or an association of genetic predisposing factors? publication-title: J Clin Endocrinol Metab – volume: 167 start-page: 1299 year: 2002 end-page: 1302 article-title: Testicular tumors in Carney's complex publication-title: J Urol – volume: 19 start-page: 298 year: 1998 end-page: 302 article-title: Psammomatous melanotic schwannoma localized in the mediastinum: Diagnosis by fine‐needle aspiration cytology publication-title: Diagn Cytopathol – volume: 97 start-page: E202 year: 2012 end-page: E206 article-title: Carney complex with adrenal cortical carcinoma publication-title: J Clin Endocrinol Metab – volume: 35 start-page: 130 year: 2007 end-page: 134 article-title: Fine‐needle aspiration cytologic diagnosis of metastatic melanotic schwannoma: familial case of a mother and daughter with Carney's complex and literature review publication-title: Diagn Cytopathol – volume: 6 start-page: 501 year: 2005 end-page: 508 article-title: Clinical phenotypes and molecular genetic mechanisms of Carney complex publication-title: Lancet Oncol – volume: 22 start-page: 60 year: 2011 end-page: 62 article-title: Intraoperative cytological findings in two cases of psammomatous melanotic schwannoma publication-title: Cytopathology – volume: 173 start-page: M85 year: 2015 end-page: M97 article-title: Carney complex: An update publication-title: Eur J Endocrinol – volume: 546 start-page: 59 year: 2003 end-page: 64 article-title: Human tumors associated with Carney complex and germline PRKAR1A mutations: A protein kinase A disease! publication-title: FEBS Lett – volume: 78 start-page: 83 year: 2003 end-page: 92 article-title: Clinical and molecular genetics of Carney complex publication-title: Mol Genet Metab – volume: 38 start-page: 94 year: 2014 end-page: 105 article-title: Malignant melanotic schwannian tumor: a clinicopathologic, immunohistochemical, and gene expression profiling study of 40 cases, with a proposal for the reclassification of “melanotic schwannoma publication-title: Am J Surg Pathol – ident: e_1_2_4_7_1 doi: 10.1016/S1470-2045(05)70244-8 – ident: e_1_2_4_8_1 doi: 10.1016/S0022-5347(05)65285-8 – ident: e_1_2_4_2_1 doi: 10.1016/S1096-7192(03)00006-4 – ident: e_1_2_4_5_1 doi: 10.1530/EJE-15-0209 – ident: e_1_2_4_9_1 doi: 10.1097/PAS.0b013e3182a0a150 – ident: e_1_2_4_11_1 doi: 10.1111/j.1365-2303.2010.00740.x – ident: e_1_2_4_6_1 doi: 10.1016/S0014-5793(03)00452-6 – ident: e_1_2_4_10_1 doi: 10.1002/(SICI)1097-0339(199810)19:4<298::AID-DC15>3.0.CO;2-I – ident: e_1_2_4_4_1 doi: 10.1002/dc.20593 – ident: e_1_2_4_12_1 doi: 10.1210/jc.2011-3327 – ident: e_1_2_4_13_1 doi: 10.1210/jc.2011-2321 – ident: e_1_2_4_3_1 doi: 10.1097/CCO.0b013e32801195eb |
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SubjectTerms | Adrenal Gland Neoplasms - diagnosis Adrenal Gland Neoplasms - genetics Adrenal Gland Neoplasms - pathology Adrenal Gland Neoplasms - surgery Adrenalectomy Calcification Carney complex Carney Complex - diagnosis Carney Complex - genetics Carney Complex - pathology Carney Complex - surgery Case reports Cyclic AMP-Dependent Protein Kinase RIalpha Subunit - genetics cytology Gene Expression Humans Literature reviews Male Mutation Nephrectomy Orchiectomy Pancreatectomy Reviews Sertoli Cell Tumor - diagnosis Sertoli Cell Tumor - genetics Sertoli Cell Tumor - pathology Sertoli Cell Tumor - surgery Splenectomy Testicular Neoplasms - diagnosis Testicular Neoplasms - genetics Testicular Neoplasms - pathology Testicular Neoplasms - surgery Testis - pathology Testis - surgery Young Adult |
Title | An adolescent with large cell calcifying sertoli cell tumor of the testis and undiagnosed Carney Complex: A case report |
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