Expression of MYD88 in Adipose Tissue of Obese People: Is There Some Role in the Development of Metabolic Syndrome?

• Published in: Metabolic syndrome and related disorders Vol. 15; no. 2; p. 80
• Main Authors: Cuevas, Ada M, Lazo, Mariana, Zuñiga, Isabel, Carrasco, Fernando, Potter, Jim J, Alvarez, Veronica, Berry, Marcos, Maluenda, Fernando, Ferrario, Mario, Clark, Jeanne M
• Format: Journal Article
• Language: English
• Published: United States 01.03.2017
• Subjects: Adipose Tissue - metabolism; Adipose Tissue - pathology; Adult; Female; Gene Expression; Genetic Predisposition to Disease; Humans; Intra-Abdominal Fat - metabolism; Intra-Abdominal Fat - pathology; Male; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Middle Aged; Myeloid Differentiation Factor 88 - genetics; Myeloid Differentiation Factor 88 - metabolism; Obesity, Abdominal - genetics; Obesity, Abdominal - metabolism; Obesity, Abdominal - pathology; Risk Factors; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; metabolic syndrome; myd88; inflammation; obesity
• ISSN: 1557-8518
• DOI: 10.1089/met.2016.0104

The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, cytokine and adipokine levels, and expression of selected genes across obese individuals with different number of metabolic syndrome (MetS) components. Forty obese individuals who underwent bariatric surgery, divided in three groups based on the number of components of MetS, in addition to abdominal obesity (0, 1, and 2-3 additional components), were studied. Levels of inflammatory proteins, insulin resistance, cytokines, adipokines, and gene expression in subcutaneous (SAT) and visceral adipose tissue (VAT) were compared. There was a significantly higher expression of MYD88 in SAT among those with more components of MetS (P = 0.008). In SAT, but not in VAT, MYD88 expression was significantly correlated with toll-like receptor 4 expression (r = 0.7, P < 0.05). Expression of adipsin in SAT was also associated with the presence of more components of MetS, but with borderline statistical significance (P = 0.05). There were no significant differences in insulin resistance, inflammation, and cytokine and adipokine levels by the number of components of MetS. Our study suggests that MYD88 expression in SAT of obese subjects could be associated with the development of components of MetS.