Vitamin C-Catalyzed Hantzsch reaction under microwave condition: A greener access to 1,4-Dihydropyridines

[Display omitted] •The present method demonstrates a mild and one pot approach to the synthesis of 1,4-dihydropyridines.•A simple and efficient vitamin C catalyzed reaction was performed under microwave irradiation.•A number of substrates were generalized through the formation of products in good to...

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Bibliographic Details
Published inResults in Chemistry Vol. 4; p. 100330
Main Authors Ray, Devalina, Naresh Yadav, Ram, Krishna Banik, Bimal
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.01.2022
Elsevier
Subjects
4-Dihydropyridine (DHP)
Hantzsch reaction
Microwave synthesis
Vitamin C
4-Dihydropyridine (DHP)
1
Microwave synthesis
Hantzsch reaction
Vitamin C
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Summary:[Display omitted] •The present method demonstrates a mild and one pot approach to the synthesis of 1,4-dihydropyridines.•A simple and efficient vitamin C catalyzed reaction was performed under microwave irradiation.•A number of substrates were generalized through the formation of products in good to excellent yields.•The plausible mechanism follows Hantzsch reaction between aromatic aldehydes and 1,3-dicarbonyl compounds. A cost effective, operationally simple and environmentally benign one-pot access to 1,4-dihydropyridine (DHP) derivatives was achieved through the successful utilization of vitamin C as catalyst under microwave irradiation. The applicability of this method was fairly demonstrated through implementation of reaction conditions on diversified substrates. A plausible mechanistic interpretation for this reaction has been outlined based on Hantzsch reaction.
ISSN:2211-7156
2211-7156
DOI:10.1016/j.rechem.2022.100330