Mouse chromosome 2

• Published in: Mammalian genome Vol. 10; no. 10; p. 941
• Main Authors: Peters, J, Church, D, Zuberi, A R, Selley, R
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.10.1999
• Subjects: Animals; Chromosome Mapping; Chromosomes - genetics; Chromosomes, Artificial, Yeast - genetics; Crosses, Genetic; Genetic Markers; Humans; Mice; Mutation
• ISSN: 0938-8990; 1432-1777
• DOI: 10.1007/s003359901121

Nearly 1400 markers are now shown on the on-line version of the Chr 2 map. These include genes, anonymous sequences and chromosome aberrations. Fifty-one new genes and 7 new quantitative trait loci (QTL) have been added since the last report. Thirty-five visible mutants map to Chr 2, including one new one, itchy (Itch), with an immunological phenotype. Itch encodes a novel E3 ubiquitin protein ligase, a protein involved in ubiquitin mediated protein degradation (45910). The wst mutation, which leads to a fatal wasting, immunological and neurological disorder, was shown to be a deletion of eukaryotic translation factor 1 alpha 2 (47466). In 1998 two historically significant autosomal transplantation antigen genes H13 and H3a, originally described by Snell in 1958 (Snell, G.D. (1958) J.Natl. Cancer Inst. 21: 843-877) as part of the first ever set of congenics, were cloned (43690, 51335).