The study of telomerase activity in gastric cancer

Telomerase activity was examined in tissue specimens from patients with gastric adenocarcinomas and gastric lymphoma using a modified TRAP (telomeric repeat amplification protocol) assay. Telomerase activity was found in 16 of 18 (89%) patients with gastric adenocarcinomas and gastric lymphoma, wher...

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Published inBiochemistry (Moscow). Supplement. Series B, Biomedical chemistry Vol. 5; no. 2; pp. 188 - 192
Main Authors Svinareva, L. V., Glukhov, A. I., Zimnik, O. V., Bykov, I. I., Khorobrykh, T. V., Shvets, V. I.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.06.2011
Springer Nature B.V
Subjects
Acid phosphatase (tartrate-resistant)
Biochemistry
Bioorganic Chemistry
Cancer
Chemistry
Chemistry and Materials Science
Enzymes
Gastrointestinal diseases
Medical diagnosis
Medicinal Chemistry
Pathogenesis
telomerase activity (TA)
gastric adenocarcinoma
telomerase
carcinogenesis
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Summary:Telomerase activity was examined in tissue specimens from patients with gastric adenocarcinomas and gastric lymphoma using a modified TRAP (telomeric repeat amplification protocol) assay. Telomerase activity was found in 16 of 18 (89%) patients with gastric adenocarcinomas and gastric lymphoma, whereas it was not detected in a patient with noncancerous gastric mucosa. Almost all analyzed specimens had “high” and “very high” levels of telomerase activity. Telomerase is almost certainly associated with the process of malignant transformation and it can be an important marker for diagnostics of gastric cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750811020168