Exciting new tools for studying TREM2 in dementia

TREM2 has long been implicated as an Alzheimer’s disease (AD) risk gene. In this issue of Structure, Szykowska et al. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the...

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Bibliographic Details
Published inStructure (London) Vol. 29; no. 11; pp. 1215 - 1216
Main Authors Menzies, Georgina E., Torvell, Megan
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 04.11.2021
Subjects
Alzheimer Disease
Humans
Membrane Glycoproteins
Receptors, Immunologic
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Summary:TREM2 has long been implicated as an Alzheimer’s disease (AD) risk gene. In this issue of Structure, Szykowska et al. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2. TREM2 has long been implicated as an Alzheimer’s disease (AD) risk gene. In this issue of Structure, Szykowska et al. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2.
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ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2021.10.009