Mycobacterium genavense infection in AIDS: imaging findings in eight patients

• Published in: European radiology Vol. 11; no. 2; pp. 193 - 196
• Main Authors: Monill, J M, Franquet, T, Sambeat, M A, Martínez-Noguera, A, Villalba, J
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01.01.2001
• Subjects: Abdomen; Abdomen - diagnostic imaging; Acquired immune deficiency syndrome; Adult; AIDS-Related Opportunistic Infections - diagnostic imaging; AIDS-Related Opportunistic Infections - microbiology; CD4 antigen; CD4 Lymphocyte Count; Chest; Computed tomography; Diagnosis, Differential; Differential diagnosis; HIV - immunology; HIV Antibodies - analysis; Human immunodeficiency virus; Humans; Infection; Intestine; Liver; Lung; Lymph nodes; Lymphadenopathy; Male; Medical research; Middle Aged; Mycobacterium genavense; Mycobacterium Infections, Nontuberculous - diagnostic imaging; Mycobacterium Infections, Nontuberculous - microbiology; Nontuberculous Mycobacteria - isolation & purification; Radiography; Retrospective Studies; Spleen; Splenomegaly; Thorax; Thorax - diagnostic imaging; Tomography, X-Ray Computed; Ultrasonography
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s003300000606

This retrospective study included eight HIV-positive patients with a M. genavense infection. Seven of these patients had a CT scan of the abdomen and a US examination, whereas one patient with pulmonary symptoms had conventional chest radiographs and thin-section CT scan of the thorax. Multiple large retroperitoneal and mesenteric lymph nodes were demonstrated in seven patients; low-attenuation centers within enlarged nodes were identified in two patients. On CT scans two cases showed circumferential wall thickening of the proximal small bowel with a deep ulceration in one of these patients. Additional findings included focal lesions in the liver (n = 1), spleen (n = 2), splenomegaly (n = 6), and hepatomegaly (n = 4). The CT scans from the thoracic examination demonstrated multiple diffuse nodular infiltrates in both lungs. M. genavense infection should be considered in the differential diagnosis of AIDS patients with CD4 counts below 100 cells/mm3 presenting with abdominal lymphadenopathy, multinodular or homogeneous hepatosplenic enlargement and circumferential thickening of the small bowel wall.