Synthetic regulation of multicellular systems for regenerative engineering

Cell therapies represent a vital pillar of the regenerative medicine approach to treating diseases. Unlike small molecules or biologic drugs, cells can integrate information from their environment to perform an array of outputs as diverse as the assembly of neotissue or engulfment of foreign bodies....

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Bibliographic Details
Published inCurrent opinion in biomedical engineering Vol. 16; pp. 42 - 51
Main Authors Lee, Joanne C., Walton, Bonnie L., Hamann, Catherine A., Brunger, Jonathan M.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 01.12.2020
Subjects
Cell therapies
Gene circuits
Synthetic morphogenesis
Synthetic morphogenesis
Cell therapies
Gene circuits
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Summary:Cell therapies represent a vital pillar of the regenerative medicine approach to treating diseases. Unlike small molecules or biologic drugs, cells can integrate information from their environment to perform an array of outputs as diverse as the assembly of neotissue or engulfment of foreign bodies. As such, cells can serve as exceptional agents to coordinate regeneration and combat disease. Regenerative medicine strategies can draw from tools developed in synthetic biology to build molecular networks that empower cells to autonomously and collectively respond to features of their niche with predefined, engineered outputs. This review summarizes recently uncovered features of natural biological systems that regenerative engineers may leverage and highlights recent additions to the expanding synthetic biology toolkit that can be readily adopted in regenerative medicine to control complex behaviors of mammalian cell collectives.
ISSN:2468-4511
2468-4511
DOI:10.1016/j.cobme.2020.100252