The price of WAR: AMR

The ongoing conflict in Ukraine has exacerbated the risk of MDR bacterial infections in war-injured patients. We present the case of a Ukrainian soldier who sustained a traumatic explosive injury to the bilateral lower extremities, underwent surgery and subsequently experienced an infection with a c...

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Published inJAC-antimicrobial resistance Vol. 7; no. 3; p. dlaf083
Main Authors Rojas, Laura J, Lemonovich, Tracy L, Marshall, Steven H, Hirschfeld, Adam, Perez, Federico, Bonomo, Robert A
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.06.2025
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Summary:The ongoing conflict in Ukraine has exacerbated the risk of MDR bacterial infections in war-injured patients. We present the case of a Ukrainian soldier who sustained a traumatic explosive injury to the bilateral lower extremities, underwent surgery and subsequently experienced an infection with a carbapenem-resistant . The isolate was subject to genomic WGS. This case study describes the successful management of a traumatic injury in a Ukrainian soldier infected with a carbapenem-resistant isolated from surgical wounds. WGS revealed a hypervirulent ST147 strain carrying multiple resistance and virulence factors, including . Treatment with ceftazidime/avibactam and aztreonam was effective. Ceftazidime/avibactam and aztreonam is highlighted as a promising regimen for MDR infections in conflict zones.
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ISSN:2632-1823
2632-1823
DOI:10.1093/jacamr/dlaf083