Hypoxia: Uncharged tRNA to the Rescue

A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity. A new study...

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Bibliographic Details
Published inCurrent biology Vol. 31; no. 1; pp. R25 - R27
Main Authors Mulroney, Thomas E., Pöyry, Tuija, Willis, Anne E.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 11.01.2021
Subjects
Amino Acyl-tRNA Synthetases - genetics
Animals
Caenorhabditis elegans - genetics
Hypoxia - genetics
RNA, Transfer - genetics
Threonine-tRNA Ligase
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Summary:A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity. A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2020.10.067