Segmentation of Pericardial Adipose Tissue in CMR Images: A Benchmark Dataset MRPEAT and a Triple-Stage Network 3SUnet

• Published in: IEEE transactions on medical imaging Vol. 42; no. 8; pp. 2386 - 2399
• Main Authors: Chen, Shuaizheng, An, Dongaolei, Feng, Chaolu, Bian, Zijian, Wu, Lian-Ming
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.08.2023; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Adipose tissue; Benchmark testing; Benchmarking; Benchmarks; Body fat; cardiac MR images; Cardiomyopathy; Cardiovascular diseases; Computed tomography; continual learning; Datasets; Deep learning; Heart Ventricles; Hospitals; Humans; Image processing; Image Processing, Computer-Assisted - methods; Image segmentation; Indexes; Magnetic resonance; Magnetic Resonance Imaging - methods; Medical diagnosis; Medical diagnostic imaging; Medical imaging; Metabolic disorders; Metabolic syndrome; multi-task learning; Myocardial infarction; Peat; pericardial adipose tissue segmentation; Pericardium - diagnostic imaging; Soil; Three-dimensional displays
• ISSN: 0278-0062; 1558-254X; 1558-254X
• DOI: 10.1109/TMI.2023.3251368

Increased pericardial adipose tissue (PEAT) is associated with a series of cardiovascular diseases (CVDs) and metabolic syndromes. Quantitative analysis of PEAT by means of image segmentation is of great significance. Although cardiovascular magnetic resonance (CMR) has been utilized as a routine method for non-invasive and non-radioactive CVD diagnosis, segmentation of PEAT in CMR images is challenging and laborious. In practice, no public CMR datasets are available for validating PEAT automatic segmentation. Therefore, we first release a benchmark CMR dataset, MRPEAT, which consists of cardiac short axis (SA) CMR images from 50 hypertrophic cardiomyopathy (HCM), 50 acute myocardial infarction (AMI), and 50 normal control (NC) subjects. We then propose a deep learning model, named as 3SUnet, to segment PEAT on MRPEAT to tackle the challenges that PEAT is relatively small and diverse and its intensities are hard to distinguish from the background. The 3SUnet is a triple-stage network, of which the backbones are all Unet. One Unet is used to extract a region of interest (ROI) for any given image with ventricles and PEAT being contained completely using a multi-task continual learning strategy. Another Unet is adopted to segment PEAT in ROI-cropped images. The third Unet is utilized to refine PEAT segmentation accuracy guided by an image adaptive probability map. The proposed model is qualitatively and quantitatively compared with the state-of-the-art models on the dataset. We obtain the PEAT segmentation results through 3SUnet, assess the robustness of 3SUnet under different pathological conditions, and identify the imaging indications of PEAT in CVDs. The dataset and all source codes are available at https://dflag-neu.github.io/member/csz/research/ .