Pharmacokinetics of sufentanil in the elderly surgical patient

• Published in: Canadian journal of anesthesia Vol. 37; no. 8; pp. 852 - 856
• Main Authors: Matteo, Richard S., Schwartz, Arthur E., Ornstein, Eugene, Young, William L., Chang, Winjing
• Format: Journal Article
• Language: English
• Published: Toronto, ON Canadian Anesthesiologists' Society 01.11.1990
• Subjects: Adult; Aged; Aging - metabolism; Anesthesia, Intravenous; Anesthetics - administration & dosage; Anesthetics - blood; Anesthetics - pharmacokinetics; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Carbon Dioxide - blood; Endarterectomy; Female; Fentanyl - administration & dosage; Fentanyl - analogs & derivatives; Fentanyl - blood; Fentanyl - pharmacokinetics; Humans; Laminectomy; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Sufentanil; Tidal Volume; Time Factors; Human; Intravenous administration; Distribution volume; Anesthetic; Radioimmunoassay; Opiates; Narcotic analgesic; Metabolism; Pharmacokinetics; Elderly; Biological activity

The effect of age on the distribution and elimination of sufentanil was studied in seven elderly (77 +/- 5 yr, mean +/- SD) and seven younger (41 +/- 15 yr) neurosurgical patients. Following a single IV bolus of sufentanil 2 micrograms.kg-1 multiple arterial samples were obtained at timed intervals...