Pharmacokinetics of sufentanil in the elderly surgical patient

• Published in: Canadian journal of anesthesia Vol. 37; no. 8; pp. 852 - 856
• Main Authors: Matteo, Richard S., Schwartz, Arthur E., Ornstein, Eugene, Young, William L., Chang, Winjing
• Format: Journal Article
• Language: English
• Published: Toronto, ON Canadian Anesthesiologists' Society 01.11.1990
• Subjects: Adult; Aged; Aging - metabolism; Anesthesia, Intravenous; Anesthetics - administration & dosage; Anesthetics - blood; Anesthetics - pharmacokinetics; Anesthetics. Neuromuscular blocking agents; Biological and medical sciences; Carbon Dioxide - blood; Endarterectomy; Female; Fentanyl - administration & dosage; Fentanyl - analogs & derivatives; Fentanyl - blood; Fentanyl - pharmacokinetics; Humans; Laminectomy; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Sufentanil; Tidal Volume; Time Factors; Human; Intravenous administration; Distribution volume; Anesthetic; Radioimmunoassay; Opiates; Narcotic analgesic; Metabolism; Pharmacokinetics; Elderly; Biological activity
• ISSN: 0832-610X; 1496-8975
• DOI: 10.1007/BF03006620

The effect of age on the distribution and elimination of sufentanil was studied in seven elderly (77 +/- 5 yr, mean +/- SD) and seven younger (41 +/- 15 yr) neurosurgical patients. Following a single IV bolus of sufentanil 2 micrograms.kg-1 multiple arterial samples were obtained at timed intervals and plasma concentrations of sufentanil were measured by radioimmunoassay. Pharmacokinetic variables were calculated from the derived compartmental models. The initial volume of distribution was significantly smaller in the elderly patients (310 +/- 109 ml.kg-1 vs 491 +/- 112 ml.kg-1 mean +/- SD). Elimination half-lives, plasma clearances, and total volumes of distribution were similar for elderly and younger subjects. Six of seven elderly patients required administration of naloxone at the termination of surgery to achieve an adequate rate of ventilation (greater than eight breaths.min-1) while only one younger patient required antagonism of ventilatory depression. The authors believe that age-related differences in the action of sufentanil cannot be accounted for by the observed differences in the initial volume of distribution. It is concluded that alterations in pharmacodynamics appear to be of greater importance in the prolonged opioid effect seen in the elderly.