Exercise capacity, cardiac and endothelial function in adults with repaired tetralogy of Fallot

Exercise capacity and endothelial function are impaired in adults with repaired tetralogy of Fallot (ToF). This may be related to pathophysiological determinants, such as cardiac and endothelial impairment, or to a more sedentary lifestyle. Therefore, we sought to assess if cardiac and endothelial f...

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Bibliographic Details
Published inInternational journal of cardiology congenital heart disease Vol. 7; p. 100327
Main Authors Novaković, Marko, Prokšelj, Katja, Jug, Borut
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2022
Elsevier
Subjects
Echocardiography
Exercise testing
Natriuretic peptides
Physical activity
Tetralogy of fallot
Vascular function
Echocardiography
Tetralogy of fallot
Physical activity
Vascular function
Exercise testing
Natriuretic peptides
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Summary:Exercise capacity and endothelial function are impaired in adults with repaired tetralogy of Fallot (ToF). This may be related to pathophysiological determinants, such as cardiac and endothelial impairment, or to a more sedentary lifestyle. Therefore, we sought to assess if cardiac and endothelial function are associated with exercise capacity in adults with repaired ToF. In a case-control study, we compared adults with repaired ToF and controls in terms of exercise workload, peak oxygen consumption (VO2peak) and flow-mediated dilation (FMD). Additionally, we determined associations of natriuretic peptide levels, echocardiographic parameters of size, function and systolic pressure with exercise capacity. A total of 26 patients (mean age 38 ​± ​10 years, 46% males) and 10 controls were included. Patients with repaired ToF had reduced VO2peak (25.0 vs. 36.3 ​ml/kg/min, p ​< ​0.001) and FMD (7.6 vs. 10.8%, p ​= ​0.007) compared to controls. Exercise workload was moderately associated with FMD (r ​= ​0.428, p ​= ​0.029) and right ventricular parameters, while VO2peak was moderately associated with natriuretic peptide levels (r ​= ​−0.523, p ​= ​0.006). Adults with repaired ToF have impaired exercise capacity and endothelial function as compared to healthy controls. Natriuretic peptide levels and FMD are moderately associated with exercise capacity in adults with repaired ToF.
ISSN:2666-6685
2666-6685
DOI:10.1016/j.ijcchd.2022.100327