Hormonal influences on the secretion of steroid-binding proteins by a human hepatoma-derived cell line

We examined the influence of numerous substances on the secretion of corticosteroid-binding globulin (CBG) and testosterone-estradiol binding globulin (TeBG) by a human hepatoma-derived cell line. Thyroxine, at physiologic concentrations, resulted in an increased secretion of TeBG but not CBG. Estro...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 59; no. 4; p. 806
Main Authors Rosner, W, Aden, D P, Khan, M S
Format Journal Article
LanguageEnglish
Published United States 01.10.1984
Subjects
Animals
Carcinoma, Hepatocellular
Cell Line
Cytosol - metabolism
Estradiol - metabolism
Humans
Liver - metabolism
Liver Neoplasms
Rats
Sex Hormone-Binding Globulin - secretion
Thyroxine - pharmacology
Transcortin - secretion
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Summary:We examined the influence of numerous substances on the secretion of corticosteroid-binding globulin (CBG) and testosterone-estradiol binding globulin (TeBG) by a human hepatoma-derived cell line. Thyroxine, at physiologic concentrations, resulted in an increased secretion of TeBG but not CBG. Estrogens, antiestrogens, and androgens were without effect on either of these binding proteins.
ISSN:0021-972X
DOI:10.1210/jcem-59-4-806