The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review

Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role...

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Published inJournal of Cancer Vol. 14; no. 2; pp. 275 - 280
Main Authors Sun, Cen-Cen, Li, Li, Jiang, Zhi-Chen, Liu, Zheng-Chuang, Wang, Liang, Wang, Hui-Ju
Format Journal Article
LanguageEnglish
Published Australia Ivyspring International Publisher Pty Ltd 2023
Subjects
Angiogenesis
Apoptosis
Bladder cancer
Cell cycle
Cell growth
Drug resistance
Gene expression
Hypoxia
Medical prognosis
Metastasis
Mortality
Mutation
Pancreatic cancer
Pathogenesis
Proteins
Tumors
Drug resistance
LncRNA UCA1
Carcinogenesis
Pancreatic cancer
Tumor progression
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Summary:Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role in different biological processes and diseases, especially in the development of tumors. LncRNA UCA1, which is firstly identified in human bladder cancer, has been showed to be a tumor promoter in pancreatic cancer. Recent researches have showed that UCA1 might promote pancreatic carcinogenesis and progression, and correlate with drug resistance. In this review, we address the biological function and regulatory mechanism of UCA1 in pancreatic cancer, which might give a new approach for clinical diagnosis and treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.79171