Epidemiology of adult meningioma: report from the Dutch Brain Tumour Registry (2000-2019)

• Published in: European journal of neurology Vol. 30; no. 10; pp. 3244 - 3255
• Main Authors: Ho, Vincent K Y, Anten, Monique M, Garst, Anniek, Bos, Eelke M, Snijders, Tom J, Eekers, Daniëlle B P, Seute, Tatjana
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2023
• Subjects: Brain; Brain cancer; Brain tumors; Central nervous system; Completeness; Diagnosis; Epidemiology; Inhabitants; Meningioma; Survival; Tumors; Netherlands; meningioma; relative survival; prevalence; incidence
• ISSN: 1351-5101; 1468-1331
• DOI: 10.1111/ene.15979

Meningiomas are the most common primary tumours of the central nervous system. This study aimed to provide comprehensive nationwide estimates on the incidence, prevalence, and prognostic impact of meningioma diagnosis in the Netherlands. Adult patients diagnosed with meningioma in 2000-2019 were selected from the Dutch Brain Tumour Registry (DBTR), part of the Netherlands Cancer Registry (NCR). Time trends in age-adjusted incidence and prevalence rates were evaluated using the estimated annual percentage change (EAPC). Relative survival rates were calculated using the Pohar-Perme estimator. Case completeness of the DBTR/NCR was estimated through record linkage with one of the Dutch neuro-oncology centres. From a total of 23,454 cases of meningioma, 11,306 (48.2%) were histologically confirmed and 12,148 (51.8%) were radiological diagnoses. Over time, the incidence of diagnosis increased from 46.9 per 1,000,000 inhabitants (European Standardized Rate, ESR) to 107.3 (EAPC 4.7%, p<0.01), with an increase in the incidence of radiological diagnoses from 14.0 to 70.2 per 1,000,000 ESR (EAPC 9.1%, p<0.01). The prevalence of meningioma was estimated at 1,012/1,000,000 on January 1 of 2020, with almost 17,800 individuals having had a diagnosis of meningioma. Relative survival rate at 10 years for grade 1 meningiomas was 91.0% (95%-confidence interval, CI: 89.4%-92.3%), 71.3% (95%CI: 66.8%-75.2%) for grade 2 meningiomas, and 36.4% (95%CI: 27.3%-45.6%) for grade 3 meningiomas. Local case completeness was estimated at 97.6% for histologically confirmed meningiomas and 84.5% for radiological diagnoses. With a near-complete registry, meningioma prevalence was estimated at over 1,000 per 1,000,000 inhabitants.