SICKLE CELL DISEASE. A SERUM DEFECT IN THE THROMBOPLASTIN GENERATION TEST

Abstract 1. A defective ability of sickle cell disease (SCD) serum to support thromboplastin generation was demonstrated. 2. The serum defect was associated primarily with homozygous SCD, although defects of varying severity were also noted in the heterozygous forms. 3. The deficiency appears to be...

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Bibliographic Details
Published inBlood Vol. 25; no. 6; pp. 907 - 920
Main Authors HENSTELL, H H, LKLIGERMAN, M, IRWIN, L E
Format Journal Article
LanguageEnglish
Published United States 01.06.1965
Subjects
Anemia, Sickle Cell
Blood Coagulation Disorders
Blood Coagulation Factors
Blood Coagulation Tests
Humans
Old Medline
Thromboplastin
BLOOD COAGULATION FACTORS
BLOOD COAGULATION DISORDERS
BLOOD COAGULATION TESTS
ANEMIA, SICKLE CELL
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Summary:Abstract 1. A defective ability of sickle cell disease (SCD) serum to support thromboplastin generation was demonstrated. 2. The serum defect was associated primarily with homozygous SCD, although defects of varying severity were also noted in the heterozygous forms. 3. The deficiency appears to be due to an accelerated loss of thrombin or thrombin-like factors from serum.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v25.6.907.907