Case Report: Plummer's adenoma in Prader-Willi syndrome

Thyroid nodules in children are less common than in adults but they are approximately two- to three-fold more likely to be malignant in children. Among thyroid nodular diseases, Plummer's adenoma occurs very rarely in pediatrics, and currently, there is no literature providing evidence of this...

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Published inFrontiers in pediatrics Vol. 12; p. 1388437
Main Authors Corica, Domenico, Toscano, Fabio, Moleti, Mariacarla, Pepe, Giorgia, Campenni, Alfredo, Fadda, Guido, Dionigi, Gianlorenzo, Romeo, Carmelo, Aversa, Tommaso, Wasniewska, Malgorzata
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 08.08.2024
Subjects
children
GH therapy
Pediatrics
Plummer’s adenoma
subclinical hyperthyroidism
thyroid nodule
GH therapy
thyroid nodule
subclinical hyperthyroidism
Plummer’s adenoma
children
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Summary:Thyroid nodules in children are less common than in adults but they are approximately two- to three-fold more likely to be malignant in children. Among thyroid nodular diseases, Plummer's adenoma occurs very rarely in pediatrics, and currently, there is no literature providing evidence of this diagnosis in patients with Prader-Willi syndrome (PWS). We report the case of a 9-year-old Caucasian boy affected by PWS presenting with a rapidly growing palpable mass in the thyroid lodge associated with subclinical hyperthyroidism. Laboratory and other examinations (thyroid ultrasound, fine-needle aspiration of the nodule, and scintigraphy) were strongly suggestive for Plummer's adenoma; therefore, the patient underwent left hemithyroidectomy surgery, and anatomo-pathological examination confirmed the diagnosis. Our case describes the first evidence of an isolated follicular adenoma in children with PWS. Surgery is the only therapeutic option in younger children. Further evidence is needed to assess the possible correlation between these two conditions and the existence of potential risk factors.
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Reviewed by: Gerdi Tuli, Regina Margherita Hospital, Italy
Małgorzata Rumińska, Medical University of Warsaw, Poland
Giorgio Radetti, Ospedale di Bolzano, Italy
These authors have contributed equally to this work and share first authorship
These authors have contributed equally to this work and share last authorship
Edited by: Mariacarolina Salerno, University of Naples Federico II, Italy
Alessandra Cassio, University of Bologna, Italy
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2024.1388437