Sex-based differences in inflammatory predictors of outcomes in patients undergoing mechanical thrombectomy: an inverse probability weighting analysis

• Published in: Therapeutic advances in neurological disorders Vol. 18; p. 17562864251345719
• Main Authors: Prandin, Gabriele, Foschi, Matteo, Valente, Mariarosaria, Zhang, Liqun, Malhotra, Paresh, Sacco, Simona, Ornello, Raffaele, Toraldo, Francesco, Maisano, Domenico, Del Regno, Caterina, Komauli, Filippo, Gartner Jarmillo, Adelaida, Al-Karadsheh, Hakam, Zahid, Hamza, Klein, Piers, Abdalkader, Mohamad, Manganotti, Paolo, Lobotesis, Kyriakos, Nguyen, Thanh N., Gigli, Gian Luigi, Banerjee, Soma, Merlino, Giovanni, D’Anna, Lucio
• Format: Journal Article
• Language: English
• Published: England SAGE Publications 01.01.2025; SAGE Publishing
• Subjects: Original Research; inflammatory markers; thrombectomy; sex
• ISSN: 1756-2864; 1756-2856; 1756-2864
• DOI: 10.1177/17562864251345719

Understanding how sex influences the inflammation response after large strokes, using a method called inverse probability weighting analysis Why was the study done? Inflammatory markers are important for predicting how well a person will recover from an ischemic stroke. These markers may affect men and women differently. This study looks at how these markers predict recovery in men and women after undergoing mechanical thrombectomy (MT) for an acute ischemic stroke. What did the researchers do? This study included 970 patients treated with MT for large vessel occlusion. Several inflammatory markers were measured when the patients arrived at the hospital and 24 hours after the thrombectomy. The study used a statistical method called inverse probability weighting to adjust for differences between male and female patients. Different statistical models were used to find predictors of good recovery and death, based on gender and age groups (<55 years and over 55 years). What did the researchers find? For men (516 patients), the analysis showed that higher admission MLR (an inflammatory marker based on blood cells) and NLR (another blood-cell-derived marker) 24 hours after the procedure were linked to better recovery. Additionally, higher MLR 24 hours after MT and ESR (a different marker) were linked to a higher risk of death in younger and older men, respectively. For women (454 patients), NLR and CRP (inflammation-related blood protein) 24 hours after MT were linked to better recovery. CRP was also associated with a higher risk of death, but there were no differences based on age in women. What do the findings mean? The study shows that men and women may have different inflammatory markers that can predict stroke recovery. For men, MLR was a key marker, while for women, CRP was more important. These findings suggest that stroke treatment and research should consider sex-based differences to improve patient outcomes.