A review on the application of bioinformatics tools in food microbiome studies

• Published in: Briefings in bioinformatics Vol. 23; no. 2
• Main Authors: Chelliah, Ramachandran, Banan-MwineDaliri, Eric, Khan, Imran, Wei, Shuai, Elahi, Fazle, Yeon, Su-Jung, Selvakumar, Vijayalakshmi, Ofosu, Fred Kwame, Rubab, Momna, Ju, Hum Hun, Rallabandi, Harikrishna Reddy, Madar, Inamul Hasan, Sultan, Ghazala, Oh, Deog Hwan
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 10.03.2022; Oxford Publishing Limited (England)
• Subjects: Bioinformatics; Computational Biology; Fermentation; Fermented food; Fermented Foods; Food; Food Microbiology; Functional foods & nutraceuticals; Metabolomics; Microbiomes; Microbiota - genetics; Next-generation sequencing; Optimization; Reviews; Starter cultures; Tactics; molecular docking; metabolomics; techniques; fermentation; microbiome; analytical tool; food
• ISSN: 1467-5463; 1477-4054
• DOI: 10.1093/bib/bbac007

Abstract There is currently a transformed interest toward understanding the impact of fermentation on functional food development due to growing consumer interest on modified health benefits of sustainable foods. In this review, we attempt to summarize recent findings regarding the impact of Next-generation sequencing and other bioinformatics methods in the food microbiome and use prediction software to understand the critical role of microbes in producing fermented foods. Traditionally, fermentation methods and starter culture development were considered conventional methods needing optimization to eliminate errors in technique and were influenced by technical knowledge of fermentation. Recent advances in high-output omics innovations permit the implementation of additional logical tactics for developing fermentation methods. Further, the review describes the multiple functions of the predictions based on docking studies and the correlation of genomic and metabolomic analysis to develop trends to understand the potential food microbiome interactions and associated products to become a part of a healthy diet. Graphical Abstract Graphical Abstract