Role of phosphatidylinositol 3,4,5-trisphosphate in cell signaling

• Published in: Advances in experimental medicine and biology Vol. 991; p. 105
• Main Authors: Riehle, Robert D, Cornea, Sinziana, Degterev, Alexei
• Format: Journal Article
• Language: English
• Published: United States 01.01.2013
• Subjects: Animals; Apoptosis; Cardiovascular Diseases - etiology; Cell Cycle; Cell Proliferation; Cytoskeleton - physiology; Diabetes Mellitus - etiology; Humans; Neoplasms - etiology; Phosphatidylinositol Phosphates - antagonists & inhibitors; Phosphatidylinositol Phosphates - chemistry; Phosphatidylinositol Phosphates - physiology; Protein Folding; Signal Transduction - drug effects; Signal Transduction - physiology
• ISSN: 0065-2598
• DOI: 10.1007/978-94-007-6331-9_7

Many lipids present in cellular membranes are phosphorylated as part of signaling cascades and participate in the recruitment, localization, and activation of downstream protein effectors. Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) is one of the most important second messengers and is capable of interacting with a variety of proteins through specific PtdIns(3,4,5)P3 binding domains. Localization and activation of these effector proteins controls a myriad of cellular functions including cell survival, proliferation, cytoskeletal rearrangement, and gene expression. Aberrations in the production and metabolism of PtdIns(3,4,5)P3 have been implicated in many human diseases including cancer, diabetes, inflammation, and heart disease. This chapter provides an overview of the role of PtdIns(3,4,5)P3 in cellular regulation and the implications of PtdIns(3,4,5)P3 dysregulation in human diseases. Additionally, recent attempts at targeting PtdIns(3,4,5)P3 signaling via small molecule inhibitors are summarized.