Epidemiologic and Clinical Clues to the Etiology of Eosinophilic Esophagitis

Despite the rising prevalence and incidence of eosinophilic esophagitis (EoE), the etiology and pathophysiology remain unknown. Studies to date suggest that complex interactions between genetic and environmental risk factors result in the development and presentation of disease. Examining environmen...

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Bibliographic Details
Published inImmunology and allergy clinics of North America Vol. 44; no. 2; p. 145
Main Authors Chang, Joy W, Jensen, Elizabeth T
Format Journal Article
LanguageEnglish
Published United States 01.05.2024
Subjects
Delayed Diagnosis - adverse effects
Eosinophilic Esophagitis - diagnosis
Eosinophilic Esophagitis - epidemiology
Eosinophilic Esophagitis - etiology
Humans
Incidence
Prevalence
Risk Factors
Early life
Environmental factors
Epidemiology
Eosinophilic esophagitis
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Summary:Despite the rising prevalence and incidence of eosinophilic esophagitis (EoE), the etiology and pathophysiology remain unknown. Studies to date suggest that complex interactions between genetic and environmental risk factors result in the development and presentation of disease. Examining environmental factors both in the early life and later life exposures offers potential clues for the development of EoE, although challenges exist in making causal inferences due to diagnostic delay and access, ascertainment biases, and misclassification of cases. The authors review studies supporting early life factors as etiologic factors in the development of EoE.
ISSN:1557-8607
DOI:10.1016/j.iac.2023.12.003