Neurobiology: From genome and connectome to understanding behavior

Many forms of synaptic plasticity are mediated by changes in the abundance, density, and expression levels of postsynaptic ionotropic receptors. A new study identifies the endogenous ligands of five ‘orphan’ aminergic ligand-gated ion channels in Caenorhabditis elegans, functionally characterizes th...

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Published inCurrent biology Vol. 31; no. 19; pp. R1135 - R1138
Main Authors Yu, Alex J., Rankin, Catharine H.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 11.10.2021
Subjects
Animals
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Connectome
Genome
Neurobiology
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Summary:Many forms of synaptic plasticity are mediated by changes in the abundance, density, and expression levels of postsynaptic ionotropic receptors. A new study identifies the endogenous ligands of five ‘orphan’ aminergic ligand-gated ion channels in Caenorhabditis elegans, functionally characterizes these channels, and explores the role of one of them in a simple form of learning. Many forms of synaptic plasticity are mediated by changes in the abundance, density, and expression levels of postsynaptic ionotropic receptors. A new study identifies the endogenous ligands of five ‘orphan’ aminergic ligand-gated ion channels in Caenorhabditis elegans, functionally characterizes these channels, and explores the role of one of them in a simple form of learning.
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2021.08.055