A drug based on water-ethanol extract of oyster mushroom mycelium displays hepatoprotective properties in experimental model of steatohepatitis

Nonalcoholic steatohepatitis in rats induced by the high-fat diet was used as an experimental model for testing hepatoprotective properties of drug based on water-ethanol extract from oyster mushroom mycelium. Progression of pathology development was monitored histologically and by biochemical assay...

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Published inBiochemistry (Moscow). Supplement series A, Membrane and cell biology Vol. 5; no. 4; pp. 364 - 369
Main Authors Polyakov, V. Yu, Golyshev, S. A., Kir’yanov, G. I., Arifulin, E. A., Gerasimenya, V. P., Zakharov, S. V., Gumargalieva, K. Z., Putirsky, Yu. L.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.12.2011
Springer Nature B.V
Subjects
Alkaline phosphatase
Basidiocarps
Bilirubin
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cholesterol
Data processing
Degeneration
Dietary supplements
Disease prevention
Drugs
Electron microscopy
Fatty liver
Food
Hepatitis
High fat diet
Life Sciences
Lipoproteins
Liver
Mollusks
Pharmaceutical sciences
Triglycerides
nonalcoholic steatohepatitis
fat dystrophy
oyster mushroom
liver
cholesterol
electron microscopy
dyslipidemia
steatosis
hepatoprotection
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Summary:Nonalcoholic steatohepatitis in rats induced by the high-fat diet was used as an experimental model for testing hepatoprotective properties of drug based on water-ethanol extract from oyster mushroom mycelium. Progression of pathology development was monitored histologically and by biochemical assay of blood samples. Subcellular response was analyzed using electron microscopy. It was shown that administration of the high-fat diet for 14 days leads to a development of adipose degeneration of liver (steatosis). Histological evidences were confirmed biochemically. Alkaline phosphatase, bilirubin, free cholesterol and lowdensity lipoprotein cholesterol levels were increased in blood of experimental animals in comparison to control. Administration of the drug was performed in parallel with high-fat food. It was shown that pathological alterations of liver in this case were reduced at both organ and cellular levels. Cholesterol and triglyceride levels were close to those in control animals. The data obtained confirm that the drug assayed can be used in clinical practice for prevention and treatment of nonalcoholic steatohepatitis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1990-7478
1990-7494
DOI:10.1134/S199074781104009X