The reactivation of human interferons by guanidine thiocyanate

The addition of 1.5 M guanidine thiocyanate (GuSCN) reactivates inactive human leukocyte interferon. The biological activity of inactivated human fibroblast interferon can be only partially recovered with GuSCN if additional (thermal) energy is supplied.

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Bibliographic Details
Published inExperientia Vol. 36; no. 12; p. 1390
Main Authors Jariwalla, R J, Sedmak, J J, Grossberg, S E
Format Journal Article
LanguageEnglish
Published Switzerland 01.12.1980
Subjects
Fibroblasts
Guanidines - pharmacology
Hot Temperature
Humans
Interferons
Leukocytes
Protein Conformation - drug effects
Protein Denaturation - drug effects
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Summary:The addition of 1.5 M guanidine thiocyanate (GuSCN) reactivates inactive human leukocyte interferon. The biological activity of inactivated human fibroblast interferon can be only partially recovered with GuSCN if additional (thermal) energy is supplied.
ISSN:0014-4754
DOI:10.1007/bf01960115