Differential effects of chitooligosaccharides on serum cytokine levels in aged subjects

• Published in: Journal of medicinal food Vol. 9; no. 3; pp. 427 - 430
• Main Authors: Kim, H.M, Hong, S.H, Yoo, S.J, Baek, K.S, Jeon, Y.J, Choung, S.Y
• Format: Journal Article
• Language: English
• Published: United States 01.09.2006
• Subjects: Aged; Aged, 80 and over; Aging; Anti-Inflammatory Agents; blood chemistry; cell-mediated immunity; chitooligosaccharides; Chitosan - chemistry; Chitosan - pharmacology; cytokines; Cytokines - blood; elderly; Enzyme-Linked Immunosorbent Assay; Humans; Immunity, Cellular; inflammation; Interferon-gamma - blood; interferons; Interleukin-1 - blood; interleukin-12; Interleukin-12 - blood; Interleukin-2 - blood; Interleukin-4 - blood; oligosaccharides; Oligosaccharides - chemistry; Oligosaccharides - pharmacology; oral administration; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - analysis; South Korea
• ISSN: 1096-620X
• DOI: 10.1089/jmf.2006.9.427

Free amine chitooligosaccharides (FACOS, Kitto Life, Seoul, Republic of Korea) with an average molecular mass of 3.5 kDa were efficiently produced using an ultrafiltration membrane reactor system. To evaluate the effect of chitooligosaccharides on serum cytokine levels in elderly adults after oral intake, 5.1 g/day of FACOS was given to elderly (age range, 74-86 years; mean, 80 +/- 3 years) volunteers during an 8-week experimental period. Interleukin (IL)-12 and interferonã levels were significantly higher in the FACOS group than in the control group (P < .05). However, levels of the inflammatory cytokines IL-1beta and tumor necrosis factor-alpha decreased after FACOS intake during the experimental period. The results of this study suggest that the oral intake of chitooligosaccharides may have beneficial effects on specific cell-mediated immunity while also acting as an anti-inflammatory agent in aged subjects.